Dementia associated with premature menopause in women, according to studies

“What we see in this study is a modest link between premature menopause and the risk of subsequent dementia,” said Dr. Donald Lloyd Jones, President of the American Heart Association. I am. He was not involved in the study.

Why do women experience premature menopause? Unless the woman has had surgery to remove her ovaries and uterus, “it is associated with more rapid biological aging of all tissues of the body, including premature aging of our organs and their functions. “Lloyd Jones said. She is a professor of preventive medicine, medicine and pediatrics at the Feinberg School of Medicine at Northwestern University in Chicago.

“When a woman experiences premature menopause, it indicates that there may be some underlying genetic, environmental or healthy behavioral problems that we really need to focus on, so much. It’s a danger signal at the level of, “he added.

Menopause before age 45

The study, which is not publicly available, was presented this week at the 2022 conference of the American Heart Association and examined data on more than 153,000 women who participated in the UK Biobank. England.

“The scope and breadth of the data is important and impressive, but it doesn’t give us the details we need to understand the full meaning of the study,” Lloyd Jones said.

This study was coordinated for age, race, weight, education and income levels, tobacco and alcohol use, cardiovascular disease, diabetes, and physical activity. Women who had menopause before the age of 45 were found to be 1.3 times more likely to be diagnosed with early-stage dementia by the age of 65.

Premature menopause between the ages of 40 and 45 Classified separately from premature menopause Before the age of 40, both can be the cause Many of the same factors: Family history; Autoimmune diseases including chronic fatigue syndrome; HIV and AIDS; Chemotherapy or pelvic radiation therapy for cancer; Surgery to remove ovaries and uterus. And smoking.

“Functional surgical menopause is at lower risk than premature biological menopause, as it can also be a danger signal for other tissues to age more rapidly, so women You really need to see a doctor and plan to optimize everything. Health factors. “

What is the role of estrogen?

As women enter the menopause, estrogen levels plummet. This may be one of the reasons for the findings, and research author Wenting Hao is a PhD candidate at Shandong University in Jinan, China.

“We know that long-term estrogen deficiency increases oxidative stress, which can increase brain aging and lead to cognitive impairment,” Hao said in a statement.

Oxidative stress occurs when the body’s antioxidant defenses cannot keep up with excess radicals or unstable atoms that can damage cells. Free radicals occur naturally in the body as a by-product of cell metabolism, but their levels can be increased by smoking, environmental toxins, pesticides, dyes, and exposure to air pollution.

“But I think premature menopause is a more important signal than just about estrogen,” Lloyd Jones said. She said, “Just like gestational diabetes or pre-eclampsia is a sign, premature menopause is a woman who is on a faster path to having problems with her heart or her brain. say.

“Let’s control everything else we can control about her diet, physical activity, weight, smoking, lifestyle changes and, if necessary, dosing,” Lloyd Jones added.

Hao said there are many ways women who have experienced premature menopause may be able to reduce their risk of cognitive decline.

“This includes routine exercise, participation in leisure and educational activities, banning smoking and drinking (and) maintaining a healthy weight,” says Hao. “Recognizing this increased risk helps women implement strategies to prevent dementia and work with doctors to closely monitor age-related cognitive status.”

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