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Need to study “overwhelming” COVID vaccine-related tinnitus

Need to study “overwhelming” COVID vaccine-related tinnitus


Editor’s Note: Find the latest COVID-19 news and guidance from Medscape Coronavirus Resource Center..

Now it is known Tinnitus Researchers say it can be an unexpected side effect of SARS-CoV-2 vaccination and there is an urgent need to understand the exact mechanism and best treatment for vaccine-related tinnitus.

As of mid-September 2021, 12,247 tinnitus or tinnitus after COVID-19 vaccination have been reported to the Centers for Disease Control and Prevention’s Vaccine Adverse Event Reporting System.

“Although some cases of ear ringing have been reported after SARS-CoV-2 vaccination, the exact pathophysiology is not yet clear,” said MBBS, a third-year student at Dow Health Science University in Karachi, Pakistan. The co-author writes with student Syed Hassan Ahmed. ..

Researchers review in an article what is known and what is not known about SARS-CoV-2 vaccine-related tinnitus Published online February 11 Annual report of medicine and surgery.

Molecular mimicry?

Based on the mechanisms behind other COVID-19 vaccine-induced disorders and the phenomenon of molecular mimicry, researchers have one possibility of cross-reactivity between anti-spiked SARS-CoV-2 antibodies and otolaryngology antigens. It states that it is sex.

“The similarity of heptapeptides between coronavirus spike glycoproteins and numerous human proteins further supports molecular mimicry as a potential mechanism behind such vaccine-induced disorders,” they write. increase.

They point out that anti-spike antibodies can react with antigens anywhere along the auditory pathway and promote an inflammatory response.

“Therefore, understanding the phenomena of cross-reactivity and molecular mimicry envisions potential treatments behind the rare events of vaccination associated with tinnitus as well as hearing loss and other otological symptoms. May help, “says the author.

Genetic predisposition and related conditions can also play an important role in determining whether an individual develops vaccine-induced tinnitus.

Post-COVID post-vaccination stress and anxiety may also play a role, as long as post-vaccination anxiety-related adverse events have been reported. They write that vaccine-related anxiety as a potential cause of tinnitus after vaccination needs to be investigated.

Judge for best management

It remains unclear how best to manage tinnitus associated with the COVID vaccine, but it begins with a well-established diagnosis, the authors say.

A well-focused and detailed history and examination is essential, with particular emphasis on existing health conditions, especially autoimmune disorders such as: Hashimoto’s thyroiditisEar scientific conditions such as sensorineural hearing loss; glaucoma; and psychological well-being. According to reviews, patients often have a history of one or more of these disorders.

“But such an association has not yet been established and further investigation is needed to conclude as a potential risk factor for vaccine-induced tinnitus,” they warn.

Regular cranial nerve tests, otoscopy, Weber tests, and phosphorus tests commonly used to diagnose tinnitus may help identify vaccine-related tinnitus.

With tinnitus Hearing impairmentAudiology also needs to be performed, the author says.

Treatments for non-vaccine-induced tinnitus vary widely, but corticosteroids are the most important treatment for SARS-CoV-2 vaccine-induced tinnitus reported in the literature.

The authors state that there is an urgent need for testing of other drugs and non-drug interventions that may independently help vaccine-related tinnitus.

In summary, the reviewer said: “COVID-19 vaccine-related otolaryngology outbreaks are rare, but a better understanding of adverse events may help to encounter vaccine hesitation, so it is necessary to identify accurate pathophysiology and clinical management. There is a promotion of the COVID-19 Global Vaccination Program.

“Despite the incidence of adverse events, the benefits of the SARS-CoV-2 vaccine in reducing hospitalization and mortality continue to outweigh the rare effects,” they conclude.

There was no special funding for this study. The author does not disclose the relevant financial relationship.

Unmed surge.. Published online on February 11, 2022. Full text

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