Health
“Zapping” air passages can result in relief of severe asthma
Friday, March 18, 2022 (HealthDay News)- InhalerPills or injections, most people have their own asthmaHowever, some people with severe illness choose state-of-the-art surgery to “modify” and improve the airways. Breathing..
Bronchial thermoplasty Contract smooth muscle lung, It prevents them from tightening and triggering an attack.U.S. Food and Drug Administration Approves Treatment for Adults Severe asthma In 2010.
According to the Cleveland Clinic, about 5% to 10% of asthma patients have illnesses that are beyond the control of medications, inhalers and other treatments.
now, New clinical trial Of the nearly 300 patients, they report a significant improvement in their symptoms 5 years after surgery.They weren’t so serious Asthma attackEmergency department visits and hospitalizations, and less corticosteroid use.
Research author Dr. Jeffrey Chap, a professor of medicine at Yale University, said: “I think it supports it Bronchial thermoplasty It should continue to be used in appropriate patients. “
The drug known as Bioforms -Another new type of treatment-Bronchial thermoplasty helps people who do not respond to these drugs, said Chap, as many patients have an increased number of asthma attacks and fewer asthma attacks. Some are treated with both biopharmacy and surgery.
The study included 284 American and Canadian patients aged 18 to 65 years who underwent bronchial thermoplasty. About 80% were followed for 5 years. They were taking corticosteroids and long-acting beta agonists to control asthma. Their asthma attacks, emergency visits, hospitalizations and substance use were followed for 12 months before surgery and 5 years after surgery.
Five years later, 9.7% were using oral corticosteroids, compared to 19.4% before surgery.
Overall, 77.8% had severe seizures before surgery, compared to 42.7% five years later. By the fifth year, hospitalizations decreased from 16.1% to 4.8% of patients and emergency department visits decreased from 29.4% to 7.9%.
In bronchial thermoplasty, the surgeon passes a catheter with a basket with four protrusions through the lungs. The prong is extended until it touches the airway wall. It then uses heat to contract the underlying smooth muscle layer so that it does not cause an asthma attack.
“What we have is a remodeling of the patient’s airways, which reduces the severity of their illness,” Chap said.
The findings were published in the March issue of the journal. chest..
asthma teeth inflammation Of the airways. Dr. Albert Rizzo, Chief Medical Officer of the American Lung Association, states that many components of the inflammation can be difficult to control.
Doctors are usually treated with anti-inflammatory drugs and drugs that dilate the airways, said Reso, who was not involved in the study.
“Why some patients don’t respond to them remains a mystery we have,” Reso said. “And it can be the result of different parts of the inflammatory pathway being poorly controlled in a particular patient. And again, this is Immune system And the genetics of the immune system, which still has much to be elucidated. “
Severe asthma affects the patient’s quality of life and is sometimes fatal, so Reso said it was important to have a cure.
The study adds evidence that the surgery is an alternative for people who do not respond well to other treatments, Reso said.
“It’s still a matter of choosing the right person: who can accomplish this and benefit from it,” he said. “And, like many other procedures, it is a procedure that should be done by an individual who has done it for a period of time. Not all lung specialists should do this. It is more skilled from doing it repeatedly. . “”
Chupp said the researchers haven’t found any long-term adverse events in the five-year data. However, there are some short-term risks.
The procedure is completed in three phases. Each phase lasts about a month, each treating different parts of the lungs. Studies show that patients are at risk of having severe asthma attacks, bleeding, and may need respiratory support. It turns out that the risk gradually diminished during years of follow-up.
Chupp hopes that further research will improve treatment and more accurately identify which patients are ideal candidates for surgery.
One of the treatment barriers: Insurers consider this procedure and may not be able to cover this procedure.
“I think bronchial thermoplasty should continue to be part of the treatment algorithm for patients with severe asthma,” Chap said. “And conduct studies that are used in combination with biopharmacy to potentially enhance disease-modifying effects so that patient outcomes can be further improved and potentially lead to clinical remission. I think we need to consider that. “
For more information
The National Institutes of Health details bronchial thermoplasty.
Source: Geoffrey Chupp, MD, Professor, Medicine, Yale University, and Director of Yale Asthma and Airway Disease Center, New Haven, Connecticut. Alberto Rizzo, MD, Chief Medical Officer of the American Lung Association in Chicago. chestMarch 2022
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Sources 2/ https://www.webmd.com/asthma/news/20220318/zapping-air-passages-may-bring-relief-for-severe-asthma The mention sources can contact us to remove/changing this article |
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