Health
Additional immune dose of mRNA vaccine protected from severe COVID-19 from Omicron
A new study confirms that booster doses of the mRNA COVID-19 vaccine provided strong protection against hospitalization and death during pandemic omicron waves in Qatar, despite its low efficacy against symptomatic infections.
Research published in New England Journal of MedicineWe analyzed data from 2,239,193 people in Qatar who received at least two doses of either the Pfizer-BioNTech or Moderna COVID-19 vaccine. In two consistent retrospective cohort studies, researchers conducted from December 19 to January 26 in patients receiving booster immunity compared to patients receiving only the double-dose primary series. We evaluated the efficacy of the vaccine during a cohort surge.
“Boosters have a significant effect because they reduce the chances of symptomatic Omicron infection by about 50%,” said research author Dr. Laith Jamal Abu-Raddad. Contagion.. “The effectiveness of boosters for COVID-19 hospitalization and death is even higher, about 80%. Having a booster recently is very protective against COVID-19 hospitalization and death from Omicron.”
The primary outcome was a symptomatic infection and the secondary outcome was a severe, severe or fatal case of COVID-19.
Among those vaccinated with the Pfizer-BioNTech vaccine, the incidence of symptomatic infections with the Omicron variant was 2.4% for those who received booster immunization and 4.5% for those who received only the primary series. The estimated efficacy of boosters for symptomatic diseases from Omicron variants was 49.4%. The efficacy of the Pfizer-BioNTech vaccine against severe, serious, or deadly COVID-19 was 76.5%. The efficacy of the Pfizer-BioNTech vaccine against the delta mutant was 86.1.
Among those who received the Moderna vaccine, the incidence of symptomatic infections with the Omicron mutant was 1% for those who received booster immunity and 1.9% for those who received only the primary series. The estimated effectiveness of boosters for symptomatic diseases from Omicron variants was 47.3%. No cases of severe, severe, or fatal COVID-19 were reported in patients who received the Moderna booster, and three severe cases were reported in patients who received only the primary series.
“The fact that there is only 50% protection against Omicron is not the best,” said Abu Raddad. “There was much better protection than 80% against previous variants such as Delta, which is a new generation of vaccines with high protection against a wide range of mutants and rapidly unabated efficacy. It suggests that we need to start thinking about development. “
To control the weakening of the immune system, this study matched exactly the pair of people according to the calendar week of the second mRNA vaccination.
“As long as there are current generations of vaccines, recent booster vaccinations are important to protect those most vulnerable to COVID-19 hospitalization and death,” said Abu-Raddad.
Abu-Raddad said researchers will continue long-term follow-up of vaccinated cohorts to see how the effectiveness of booster shots declines over time.
Recent studies have shown that the efficacy of RNA vaccines against COVID-19 declines over time.Centers for Disease Control and Prevention report Hospitalization protection during the Omicron wave was reduced from 91% after 2 months to 78% after 4 months of mRNA booster.
A Recent research Decreased defense after complete vaccination was found to be more important for vaccine efficacy than for delta mutant emergencies.
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