Cancer Detection: Fine worms on the chip can be trained to sniff out tumor cells

To Claire Wilson

Move over Fido.The next animal that helps people by sniffing cancer It may be a microscopic worm.

Nematodes, also known as roundworms, are attracted to compounds released by lung cancer cells. When placed in a small device, nematodes (Caenorhabditis elegans) Early-stage studies have shown that they wriggle towards cancerous cells rather than non-cancerous cells.

This approach could be a diagnostic test for lung cancer that could use samples of people’s urine and saliva, said Nari Chan of Meiji University in South Korea.

Other researchers are trying to train Dogs that detect cancerHowever, nematodes also have a sense of smell. This is important for sniffing out food, usually bacteria and fungi. In previous surveys I’m attracted to urine From people with different types of cancer.

Cancer cells differ biochemically from non-cancer cells in many ways. A compound called 2-ethyl-1-hexanol, which has a floral scent, seems to attract nematodes. “I think the smell is similar to the smell of their favorite food,” Chan said in a statement.

Chan’s team created a test kit containing a small chip containing some of the 1 mm long nematodes in a central chamber and connected to two wells on the opposite end of the chamber. Place the chip on an agar plate, place a drop of liquid taken from a dish containing cancer cells next to one well, and place liquid from non-cancer cells next to the other well. In the test, more nematodes migrated towards the cancer cell fluid in an hour.

Tests have shown that devices containing nematodes have about 70 percent accuracy in detecting the presence of cancer cells. This isn’t high enough to be used as a medical test, but if the nematodes are trained to respond to the scent of flowers, accuracy is likely to improve, Chan said. ..

Nematodes have surprisingly good memories of environmental cues like scents, so the idea may sound, but it’s not strange, says. Lindy Holden Dye At the University of Southampton, UK. “Worms are very easy to maintain and don’t take up a lot of space,” she says. “They are relatively sophisticated in what they can do.”

The work was announced at American Chemical Society Meeting in San Diego this week.

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