After taking cranberries daily for a month, men’s vascular function improved.Researchers cranberry What was needed to achieve these benefits was realistically achievable.
In a new study published in the journal Hood & FunctionResearchers at King’s College London and Sally University have set out to investigate the effects of overall frost-dried cranberry consumption on healthy men.
Although previous studies have shown cardiovascular health benefits from cranberry juice intake, it is unclear whether daily intake of cranberries as a whole persisted in vascular benefits.
Their study conducted a double-blind, parallel-group, randomized controlled trial involving 45 healthy men aged 18-45 years with no cardiovascular disease. Coronary artery diseaseCerebrovascular accident and Peripheral artery disease -Diabetes, acute inflammation, end-stage renal disease, malignant tumors, and non-sinus heart rhythm.
Twenty-three men consumed 100 g of fresh cranberry equivalent of whole cranberry powder (9 g powder) per day, and 22 men consumed placebo for one month. This main study followed a successful pilot study of five healthy men to confirm the biological activity of the entire lyophilized powder of cranberries.
The primary end point of this study is to measure how blood vessels expand when blood flow increases through measurements of brachial artery diameter and flow velocity, which is considered a sensitive biomarker for cardiovascular disease risk. It was mediated dilation (FMD).
Secondary endpoints were pulse wave velocity (PWV), aortic augmentation index (AIx), blood pressure, heart rate, and blood. LipidsAnd blood sugar.
Evaluations were made at baseline, 2 hours on day 1, and 1 month later. Plasma and 24-hour urine were also analyzed before and after treatment.
Improvement of heart and blood vessel function
Researchers say that people taking cranberries “show improvement in heart and vascular function” compared to 1.1% (95% CI: 1.1%, 1.8%) control of FMD. These improvements have shown FMD both “immediate and long-term benefits.” In addition, metabolites were identified and the positive effects seen with FMD were predicted.
Dr. Anna, a senior lecturer in nutrition at King’s College London and a senior author of the study, said: Prevention of cardiovascular disease. “
However, the authors stated that the secondary results showed no significant difference between the response to cranberries and the control intervention.
Achievable cranberry consumption
Dr. Christian Heiss, a professor of cardiovascular medicine at Sally University and co-author of the study, said: Cardiovascular risk.. This study further shows that certain metabolites present in the blood after cranberry ingestion are associated with beneficial effects. ”
The authors pointed out some limitations of the study, including how the study was conducted in a healthy cohort of young male volunteers. Therefore, the potential for generalization to the general population and high-risk people is limited.
They also stated that a short one-month study period limits conclusions about potential clinically relevant health benefits that require short-term vasoprotective effects to be maintained over a long period of time. .. “Along these lines, some potential health benefits that may take longer to appear may not be detected,” they said.
The authors explained that low fruit and vegetable consumption is one of the correctable risk factors associated with a high incidence of cardiovascular disease worldwide. “These results show that cranberry intake as part of a healthy diet can play an important role in supporting cardiovascular health and good vascular function,” they said. Told.
“The fact that these improvements in cardiovascular health were seen in the amount of cranberries that could be reasonably consumed daily made cranberries an important fruit in the prevention of cardiovascular disease in the general population,” said Dr. Rodriguez Mateos. I emphasized.
This study was supported by the Cranberry Institute, which provided the entire cranberry and placebo powder.
