A trio of analysis based on the future UK Biobank cohort suggests that regular coffee drinking, especially 2-3 cups daily, may not only be safe for the heart, but may also protect the heart. I am.
Compared to non-coffee drinkers, those without cardiovascular disease (CVD) at that level of coffee intake have a significantly reduced risk of death and various CVD endpoints, 8% in about 10 years. Decreased in the range of 15%. ..
Another analysis also showed that participants with baseline CVD showed a significant improvement in survival and no increased risk of arrhythmia with 2-3 cups of coffee daily.
In the third cut of UK Biobank data, the same level of coffee is consumed, whether it is an “instant” type for reconstitution with water or brewed from ground whole beans. The clinical benefits of drinking coffee have been observed.
Some clinicians advise patients that drinking coffee can cause or exacerbate certain types of heart disease. However, current analysis suggests that “daily coffee should not be stopped, but should be considered part of a healthy diet.”
Kistler and his colleagues will present three UK Biobank cohort analyzes individually at the American College of Cardiology (ACC) 2022 Scientific Session, which will be held virtually and directly in Washington, DC from April 2. am. Data and comments were made at a press conference prior to the meeting.
On average, UK Biobank survey participants in their late 50s reported their daily coffee intake and preferred coffee type in a survey. Researchers have generally observed a U-shaped relationship between the number of coffee cups per day and accidental CVD. heart failure, Coronary heart disease (CHD), stroke, Atrial fibrillationArrhythmia, and death for more than 10 years.
“I think this is music for many of our patients’ ears, and for many in the field of cardiology. Our people who get up early and late in the hospital have a fair amount of coffee. It consumes, “Katie Berlacher observed. , MD, Deputy Chief of Heart Education at the University of Pittsburgh Medical Center, Pennsylvania.
The analysis was based on a large cohort and found consistent patterns for several cardiovascular outcomes, said Berlacher, vice chair of the ACC science session.
Many of us warn patients with or at risk of developing CV, so the results of this study “may have a significant impact on routine clinical care.[D] For coffee consumption, “she said. theheart.org | Medscape Cardiology on mail.
“These studies suggest that there is no objective evidence to warn or ask patients to stop drinking coffee, including those with arrhythmias.”
But importantly, she added, “these studies are not causal.” “Therefore, we cannot recommend coffee consumption, but we can think that a randomized prospective study should be done to elucidate the causality.”
“Coffee is the most common cognitive enhancer, it awakens you, makes you mentally sharp, and is a very important element of many people’s daily lives,” Kistler said in an email. theheart.org | Medscape Cardiology. “The takeaway message is that clinicians should not advise patients to stop drinking up to three cups of coffee a day,” he said.
“There is no data to suggest that people who don’t drink coffee should start drinking coffee,” he said. In addition, you do not necessarily need to increase your coffee intake, especially if you feel anxious or uncomfortable.
Benefits with or without known heart disease
The researchers identified 382,535 participants in the UK Biobank Cohort who had no CVD at baseline. The median age was 57 years, with 52% being female.
Those who report that they regularly consume 2-3 cups of coffee daily compared to those who do not drink coffee are at risk of CVD, CHD, heart failure, arrhythmias, and death from any cause for more than 10 years. It showed a significant decrease (P <.01 (all endpoints). The hazard ratio (HR) and 95% CI are:
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HR, 0.91; 95% CI, 0.88 to 0.94 for CV disease
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HR, 0.90; 95% CI, 0.87 to 0.93 for CHD
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HR, 0.85; 95% CI, 0.81 to 0.90 for heart failure
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HR, 0.92; 95% CI, 0.88 to 0.95 for arrhythmias
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HR, 0.86; 95% CI, 0.83 to 0.90 for deaths of any cause
The risk of death from cardiovascular disease reached its lowest point with a single daily intake (HR, 0.83; 95% CI, 0.75-0.93). The risk of stroke was lowest with less than one cup daily (HR, 0.85; 95% CI, 0.75-0.96).
Another analysis found similar results among different subsets of UK Biobank participants with CVD recognized at baseline. Of the 34,279 such individuals, those who drank 2-3 cups of coffee a day showed a reduced risk of death over 10 years (HR, 0.92). 95% CI, 0.86-0.99; P = .03).
Of the 24,111 people diagnosed with arrhythmia at baseline, the lowest risk of death was observed at 1 cup daily (HR, 0.85; 95% CI, 0.78-0.94; P <.01).Among people with atrial fibrillation Atrial flutter1 cup daily was associated with a mortality rate of 0.82 HR (95% CI, 0.73-0.93; P <.01).
In yet another analysis of the UK Biobank cohort, during a 10-year follow-up between freshly brewed coffee and participants who reported consumption of instant coffee individually compared to non-drinkers. Incident CVD and mortality have been reduced as well. Caffeinated coffee showed a little neutral or inconsistent effect on the clinical endpoints.
The lowest CVD risk is for those who regularly drink ground coffee (HR, 0.83; 95% CI, 0.79-0.87) and those who mainly drink instant coffee (HR, 0.91; 95% CI, 0.88-0.95). It was observed in 2-3 cups a day. ).
Potential mechanism, research limits
“”caffeine block Adenosine Receptors may explain their potential mild antiarrhythmic properties, “Kistler said. Supraventricular tachycardia When you come to the emergency department, you often need to increase your adenosine dose to get it back. “
Caffeine plays a role in weight loss through inhibition of intestinal fatty acid absorption and an increase in basal metabolic rate, and coffee is associated with a significant reduction in the risk of new developments. Type 2 diabetes..
However, he states that coffee beans contain over 100 biologically active compounds. They contain antioxidant polyphenols that reduce oxidative stress and regulate metabolism.Better survival through habitual coffee consumption may be associated with improved endothelial function, antioxidant circulation, and improved Insulin Researchers pointed out that susceptibility, or reduction of inflammation.
They acknowledge some restrictions on the analysis. It is not possible to identify the cause and effect from the observation data. Also, a cup of coffee in the UK means brewing about 200ml to 250ml, but the actual caffeine content varies from 90mg to 250mg. There was also a lack of data on the addition of sugar and milk. Also, because UK Biobank participants are primarily Caucasian, it may not be possible to generalize the findings to other populations.
American College of Cardiology 2022 Science Session.
Effects of habitual coffee consumption on accidental cardiovascular disease, arrhythmias, and mortality: findings from UK Biobank. Announced on April 3rd. Overview.
Regular coffee consumption is associated with improved mortality from common cardiovascular disease. Announced on April 2nd. Overview.
Ground coffee, instant coffee, decaffeinated coffee? Impact of various coffee subtypes on incident arrhythmias, cardiovascular disease, and mortality. Announced on April 3rd. Overview.
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