Health
First use of mRNA COVID vaccine to treat persistent SARS-CoV-2 infection
New case report published in Journal of Clinical Immunology Presented the first description of the mRNA COVID-19 vaccine used to treat patients experiencing persistent SARS-CoV-2 infection therapeutically. Patients with immunodeficiency were found to test positive for SARS-CoV-2 for more than 6 months, receive two mRNA vaccines, and finally remove the virus from the system.
Viral infections are usually characterized as either acute or chronic. Chronic viral infections such as herpes and Epstein-Barr virus are often undetected for long periods of time. The virus has been dormant for years and can sometimes reactivate, causing physiological symptoms and new waves of infectivity.
Rarely, people with weakened immunity may experience a form of chronic viral infection known as persistent infection. In these cases, the virus can remain acutely active for several months, and the patient consistently experiences negative symptoms and sheds infectious virus particles.
As far as we know, this is the first time mRNA vaccination has been used to eliminate persistent COVID-19 infection.
A new study by British researchers reports a case of a 37-year-old man named Ian Lester who experienced persistent SARS-CoV-2 infection and had a consistent positive PCR test for 218 days. Lester suffers from a rare genetic disorder called Wiskott-Aldrich Syndrome, which initially showed very mild COVID-19 symptoms.
“Most people can stop quarantining 10 days after being infected with the virus, but I was an exception to the rule,” Lester said. “Each test returned positive over and over again. After months, I felt like I couldn’t go anywhere or meet friends and family. “
Over time, Lester returned a positive PCR test every two weeks, worsening her symptoms. Blood tests 5 months after infection showed no SARS-CoV-2 antibody. This indicates that his immune system did not respond to the invading coronavirus at all. Stephen Jolles, clinical leader at Cardiff University, thought it was time to try more treatments.
“Given the persistent positive PCR test and its impact on his health and mental health, we decided on our own therapeutic approach,” said Jolles. “We wondered if therapeutic vaccination would ultimately help eliminate the virus by eliciting a strong immune response in the body.”
The team vaccinated Pfizer twice with Pfizer’s mRNA COVID-19 vaccine approximately every four weeks. Within 14 days of the first dose, PCR tests showed a clear reduction in the amount of viral material collected in each nasopharyngeal swab. Approximately 6 weeks after the second dose, Lester was negative for SARS-CoV-2 for the first time for 218 days.
“It was a pretty amazing moment,” said Mark Ponsford, another clinician working on the case. “As far as we know, this is the first time mRNA vaccination has been used to eliminate persistent COVID-19 infection. Importantly, the vaccine is well tolerated by patients and has strong antibodies and T cells. It successfully induced a cellular response. This is noteworthy given that Ian’s response to previous conventional vaccinations was very limited. “
Case studies, along with more traditional prophylactic approaches, are a compelling example of how mRNA vaccines can be used for therapeutic purposes. Therapeutic vaccines help encourage the immune system to target existing illnesses. Currently, a lot of research is focused on About therapeutic vaccines Target various cancers..
The new study was published in Journal of Clinical Immunology..
sauce: Cardiff University
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