Test confirms COVID-19 as a trigger for the rare Kawasaki-like syndrome in children

A test developed by Birmingham experts provides evidence confirming that COVID-19 is responsible for the emerging multisystem inflammatory syndrome in children tested negative for the virus by PCR testing. did. This means that a child who may have been infected by a virus in their system, although not feeling ill, may be at risk of developing this new condition.

In the last few weeks of the COVID-19 pandemic, Children It has the same symptoms as Kawasaki disease. A rare condition, usually below 5 degrees, that causes persistent high temperatures, rashes, and vascular inflammation. This new condition, recently called Pediatric Inflammatory Multisystem Syndrome, is temporarily associated with SARS-CoV-2 (PIMS-TS), affecting approximately 100 children in the UK to date, Further cases have been reported throughout Europe and the United States.

This latest study demonstrates the value of an antibody test developed by a team at the University of Birmingham to confirm the diagnosis of children hospitalized with symptoms consistent with PIMS-TS. All children were PCR negative for SARS-CoV-2 virus. This study was conducted by The University of Birmingham, Birmingham Health Partner, Birmingham Women’s NHS Foundation Trust, University Hospital Birmingham NHS Foundation Trust, University of Southampton, The Binding Site Group Ltd.

Blood tests showing the presence of different types of antibodies to the virus have shown that all children have high levels of anti-SARS-CoV-2 antibodies. Pattern antibody It indicated that the infection probably occurred weeks or months ago. This means that antibody tests can be used to help diagnose PIMS-TS even when the virus cannot be detected directly in the patient.

Dr. Alex Richter, a principal investigator and consultant immunologist at the Institute of Immunology and Immunotherapy at the University of Birmingham, said: -CoV-2 infection. This test is used to understand the number of people in the community who are suffering from COVID-19, but among these, we find another use to identify PIMS-TS Sick child“

According to Adam Cunningham, a co-author and professor of functional immunity at the University’s Institute of Immunology and Immunotherapy, This allows them to choose the best lifesaving treatment. “

Dr. Barney Scallfield, a Pediatric Intensive Care Consultant at the Birmingham Women’s and Children’s NHS Foundation Trust and a researcher at the University’s Institute for Inflammation and Aging, said: “Advanced immunology expertise and access to new high-sensitivity antibodies test At the University of Birmingham, it was essential to enable rapid diagnosis and early treatment of these very ill children with PIMSTS. ”

Dr. Fiona Reynolds, Chief Medical Officer of the NHS Foundation Trust at Birmingham Women’s and Children’s Trust, said: This is very important for a better understanding of the disease and, most importantly, how to provide the best treatment. ”

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COVID-19 may be associated with a rare inflammatory disease in young children

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Tests confirm that COVID-19 triggers rare Kawasaki-like syndrome in children (June 8, 2020)
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