Health
Researchers at IIT Madras Show Relationship Between Tongue Cancer Cell Growth and Spread
Indian Institute of Technology Madras Researcher has identified a specific microRNA (miRNA) called “miR-155” that is overexpressed in tongue cancer. This finding is important in that we can devise molecular strategies to manipulate the expression of miR-155 and develop therapeutics for tongue cancer.
miRNAs affect cancer growth by inhibiting or enhancing the function of certain proteins. For example, a type of protein called “programmed cell death 4” has been shown to help block the growth and spread of cancer cells. Inhibition of this protein is known to cause the spread of oral, lung, breast, liver, brain, and colon cancers.
IIT Madras research team discovers the reasons behind the growth of several types of cancer
In this study, a team of researchers headed by Professor Devarajan Karunagaran, Dean of Biotechnology at IIT Madras, and researcher Shabir Zargar, conducted a study at the Cancer Research Institute in Chennai, the Three Balaj Dental University Hospital, and the Indian Science Institute in Bengaluru. Cooperated with the person. ..
Relationship between cancer cells and tumor growth
To elaborate on the study, Professor Carnagaran, Dean of Biotechnology at IIT Madras, said: They have been found to play an important role in metastasis in many cancers, carcinogenesis (onset of cancer), malignant transformation, and development of secondary cancers. The miRNAs associated with cancer are called “Oncomirs.” “
In addition, Professor Karnagaran adds: “Many tumors affect cancer by suppressing the ability of tumor suppressors to prevent tumor cell growth and metastasis. Therefore, miRNAs associated with both cancer cell suppression and growth It’s important to identify the type.”
The team does more than just show the connection between the miR-155 and pdcd4. They also showed that knocking out miR-155 causes cancer cell death, arrests the cell cycle, reduces tumor size in animal models, and reduces cell viability and colony formation in benchtop assays. It was
In addition, researcher Shabir Zargar said, “It has long been suspected that miR-155 downregulates Pdcd4, but until now there was no evidence of such an interaction.”
A collaborative team, led by Professor Karnagaran, has unequivocally demonstrated that miR-155 is overexpressed in tongue cancer cells and tumor tissue. This “overactivity” of miR-155 interferes with the action of pdcd4, causing the spread and growth of tongue cancer.
“Our study shows that restoration of Pdcd4 levels through molecular manipulation of miR-155 may lead to the development of potential treatments for cancer, especially tongue cancer,” adds Karunagaran. ..
The cure that addressed this process
Manipulation of miRNAs has been combined with traditional cancer therapies such as chemotherapy, radiation and immunotherapy, and the study reported by the joint team could enable new treatments for such cancers. I can do it.
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