Erectile dysfunction medication and risk of eye damage

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• Researchers say men who regularly use erectile dysfunction medications may be at increased risk of eye damage, including retinal detachment.
• According to experts, the link between these medications and eye health has been documented in recent years, and their effects are usually temporary.
• They add that people should not take these medicines entertainingly because of potential side effects.

According to a new study, men taking erectile dysfunction medications can develop serious eye problems, including retinal detachment.

Leading research Mahal EtominanPharmD, an associate professor of ophthalmology and visual science at the University of British Columbia, was conducted from 2006 to 2020 using data obtained from the Pharmatrics Plus database.

the study It was published in JAMA Ophthalmology. Participants consisted of 213,000 men who took erectile dysfunction (ED) medications such as sildenafil, tadalafil, vardenafil, and avanafil.

“Mechanistically, the study found that PDE5I may be associated with reduced optic nerve perfusion,” the study’s author writes. “In addition, it is hypothesized that choroidal vessels may undergo smooth muscle relaxation via the cyclic guanosine monophosphate pathway, which can lead to choroidal congestion.”

The authors pointed out that there were 20 million monthly prescriptions for these drugs in the United States in 2020.

“Given the lack of data on the popularity of these agents and the magnitude of the risk of SRD (serous retinal detachment), RVO (retina ischemic syndrome), and ION (ischemic optic neuropathy), we are large. We sought to conduct a cohort study of SRD, RVO, and ION associated with the use of PDE5I, “they write.

The authors of the study reported that there were 1,146 cases, including eye health problems. This includes 278 SRDs, 628 RVOs and 240 IONs. The average age of all participants was almost 65 years.

“Patients with SRD, RVO, and ION were more likely to suffer from hypertension, diabetes, coronary artery disease, and sleep apnea,” the authors said.

“The results of this cohort study suggest that regular users of PDE5I may be at increased risk of SRD, RVO, and ION. Regular users of PDE5I have eye hazards associated with these drugs. You need to be aware of the event and warn your doctor if you experience a visual impairment, “the author writes.

The authors stated that the results of the study, which claims to be the largest of its kind, are “contradictory.”

“The results of this cohort study not only confirm the results of other studies on the risk of ION associated with the use of PDE5I, but also the risk of SRD and RVO associated with the use of these previously unassessed drugs. Quantify, “the author writes.

Dr. Yuna LapoportHealthline, a board-certified ophthalmologist in Manhattan Eye, New York, said ophthalmologists are already aware of the link between ED use and eye health.

“ED drugs like Viagra and Cialis are known to cause eye side effects such as blue tint, blurred vision, and photosensitivity to everything that is visible, but these are all relatively temporary. Yes, it has a relationship with its inhibitory effect on PDE6, which is present only in the rod and pyramidal photoreceptors of the retina, “Rapoport said.

“For blue vision (blue shades on everything visible), patients usually have a temporary red-green dysfunction (these colors look brown) and all have blue shades,” Rapoport said. Added. “These are temporary. There is one condition-NAION-or non-arterial ischemic optic neuropathy-permanent and can be caused by ED drugs. People at risk of NAION (in the optic nerve) If you have a small cup-to-disc ratio, or if the disc is at risk), taking ED medications will dilate your blood vessels and lower your blood pressure. “

“There are some individual case reports of retinal detachment in ED supplements such as arginine in patients who are already predisposed, but retinal detachment is generally not considered a known side effect of ED drugs,” Rapoport said. I am saying.

A pharmacist working with ED medications told Healthline that users should not be taken for recreation if they do not have erectile dysfunction.

“When taking erectile dysfunction medication carefully under supervision, after consulting with a practitioner, studies have shown that it has no lasting toxic effects on choroidal retinal tissue and photoreceptors,” he said. .. Matt RezaeiCEO of Digital Pharmacy, Canada Upguys.. “We need to prevent patients from overdose. Taking ED medications for recreation can have negative side effects.”

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