Health
Aging: Scientists say skin cells can be younger
British scientists say they developed New technique It can rewind the aging of skin cells for about 30 years.
Published in the journal eLifeIn a news release, researchers at the Babraham Institute’s Epigenetics Research Program said they had partially restored the function of old cells without losing their special function.
These partially rejuvenated cells also showed signs of behaving like more youthful cells.
Although still in the early stages, they say that if replicated in other cell types, research could impact regenerative medicine and produce cells that excel in wound healing.
“Our results represent a major step forward in understanding cell reprogramming,” said postdoctoral fellow Dirgito Gil, who studied as a PhD student, in a statement.
“We have shown that cells can be rejuvenated without loss of function, and that rejuvenation appears to restore some function to older cells. There was also a reversal of the aging index of disease-related genes. The facts are particularly promising for the future of this research. “
Researchers say that one of the most important tools in regenerative biology is the ability to create induced stem cells, which involves erasing some of the markers that specialize the cells.
However, instead of completely erasing the cell’s identity in research, researchers have created stem cells using a new method called temporary reprogramming during maturity based on Nobel Prize-winning technology. bottom.
The new method stops reprogramming prematurely, allowing scientists to regain special functions while making cells biologically younger.
In this case, further analysis reveals that the cells regain the markers characteristic of skin cells or fibroblasts, produce more collagen proteins than cells that have not undergone the reprogramming process, provide structure to the tissue, and wound wounds. Helped to heal.
Scientists then tested the rejuvenated cells by making artificial cuts in the layer of cells in the dish.
Experiments have shown that treated fibroblasts move to the gap faster than older cells.
Not only did the reprogrammed cells “time-jump” by 30 years, but the method also affected other genes associated with age-related diseases such as Alzheimer’s disease and cataracts, researchers said. increase.
“This study has very exciting implications,” said Professor Wolf-Like, who led the study.
“Ultimately, it may be possible to identify genes that rejuvenate without reprogramming and target them specifically to reduce the effects of aging. This approach can open up amazing therapeutic horizons. It has the potential for valuable and sexual discoveries. “
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