Health
Psilocybin therapy may improve symptoms of depression: studies
April 13, 2022 – Treatment with Psychedelic Silocibin (also known as Magic Mushroom) Symptoms of depression,according to Small study Was announced in Nature medicine..
Researchers write that people with depression should not give themselves medicine. mental health Experts were involved. However, they said the treatment could show hope for the future.
“Depression is a very prevalent mental health condition, the incidence of which is increasing during COVID-19. Pandemic“But even the best performing antidepressants show modest effects, non-negligible side effects, discontinuation problems, high recurrence rates, and new and improved treatments,” they wrote. It highlights the need. “
Researchers at Imperial College London analyzed brain scans of 60 people in two trials given psilocybin. In the first study, all were given two doses of 10 mg and 25 mg of oral psilocybin at 7-day intervals.functional Magnetic resonance image, Or fMRI – a test to measure brain activity – was done before treatment and the day after 25 milligrams of dosing. Doctors measured the symptoms of depression after treatment.
In the second trial, some received psilocybin therapy and others took the common escitalopram. Antidepressant.. Patients with major depressive disorder receive either two 25 milligram doses at 3-week intervals and daily placebo for 6 weeks, or 1 milligram dose twice at 3-week intervals and daily escitalopram for 6 weeks. I did. fMRI was performed before treatment and 3 weeks after the second dose of psilocybin.
Psilocybin treatment showed improvement, and the brain network became more connected and flexible.
“In both trials, the antidepressant response to psilocybin was rapid and persistent, correlating with reduced modularity of the fMRI brain network, and the antidepressant effect of psilocybin relied on a global increase in brain network integration. It may be, “they write.
In addition, the reaction of antidepressants Escitalopram They said they were milder and showed no changes in the brain’s network tissue.
At least 6 people in the last 15 years Clinical trials Researchers have reported improvement in depressive symptoms with psilocybin therapy. Two trials conducted in 2015 and 2019 were included in this analysis.
“Depression is a major public health problem associated with enormous burdens and costs,” they write. “Here we identify a robust, reliable and potentially specific biomarker for the response to psilocybin therapy for depression.”
The authors write that the findings are promising, but successful Phase III clinical trials will be needed to promote approval for psilocybin treatment as a available option.
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Sources 2/ https://www.webmd.com/depression/news/20220413/psilocybin-therapy-depression-study The mention sources can contact us to remove/changing this article |
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