As part of World Immunization Week 2022, News Medical speaks to the International Vaccine Institute about their fight against vaccine inequity, as well as what a “Long Life for All” means to them.
Please can you introduce yourself and tell us about what the International Vaccine Institute is and the work that you do?
My name is Jerome Kim, M.D., and I am the Director General of the International Vaccine Institute (IVI), an OECD-recognized international organization established in 1997 at the initiative of the United Nations Development Programme (UNDP). IVI is now an independent entity with 38 countries and the World Health Organization as member states.
We work with governments, vaccine developers and manufacturers, philanthropies and foundations, other international organizations and public-private partnerships, policymakers, universities, hospitals, and the private sector to make safe and effective vaccines available and accessible for global public health.
As an organization, your mission is to discover, develop and deliver safe, effective, and affordable vaccines for global public health. Can you tell us more about how you are working towards this goal?
IVI focuses on vaccines that are critically needed to prevent and eradicate infectious diseases that disproportionately and widely affect low- and middle-income countries. These diseases are often associated with poverty, such as cholera, typhoid, schistosomiasis, and other Neglected Tropical Diseases (NTDs), resulting in a lack of financial incentive for major vaccine developers to invest in vaccine development. IVI aims to close this gap, advocating for, gaining funding, and developing new and improved vaccines that will save and improve hundreds of thousands of lives every year.
IVI works at every stage of vaccine development, from the prerequisite epidemiology research to understand the burden of infectious diseases in particular regions; pre-clinical development in the lab to discover and test vaccine candidates; clinical trials to assess safety, immunogenicity, and efficacy in human volunteers; vaccination campaigns to evaluate how well vaccines protect populations in real settings; and advocacy to educate governments and the general public on the importance of vaccines and vaccination.
IVI also recognizes that health is a precondition to living a full and productive life. We see our work to prevent and eradicate infectious diseases as innately linked to achieving other global goals (what the UN calls Sustainable Development Goals), such as Quality Education (immunized children don’t miss school due to preventable illness), No Poverty (parents don’t have to miss work to care for sick children), and Reduced Inequalities (helping to close income gaps), among others.
The approach of the International Vaccine Institute has three components: research, partnerships, and capacity-building. Please could you tell us more about what each of these components means for accelerating vaccines for public health?
As a research institute, we identify the need for a vaccine through epidemiology and begin testing new vaccine candidates for diseases with a high burden and little financial incentive. For instance, IVI developed the world’s first affordable oral cholera vaccine and transferred the technology to two vaccine manufacturers, Shantha Biotech in India and EuBiologics in South Korea, to bring them to the global public market. These WHO-prequalified vaccines were available at $1.85 per dose, in contrast to Dukoral®, an existing cholera vaccine that was also purchased by the public sector though used primarily as a traveler’s vaccine due to its cost and delivery requirements.
Achieving WHO Prequalification, the only global medicines quality assurance program enables agencies such as UNICEF to purchase vaccines for global public use. We’re pursuing a similar pathway for a new typhoid conjugate vaccine (Vi-DT) which has now completed Phase III clinical trials, and we’re in the early stages of developing vaccines for invasive non-typhoidal Salmonella (iNTS) and Shigella, two infectious diseases that may kill 500,000 people every year with no licensed vaccines to protect against them.
Our distinctive model as both a research institute and product development partner affords us unique capabilities to seamlessly transition from the lab to technology transfer to clinical development and all the way to licensure and delivery.
Beyond the laboratory stage, we conduct epidemiology research and disease surveillance as well as vaccine clinical trials, prioritizing settings with a high disease burden but limited opportunities to participate in clinical development. We evaluated Vi-DT in Nepal, for example, a country with one of the highest burdens of typhoid in the world but little capacity or infrastructure to carry out clinical trials. Capacity-building has been one of IVI’s core mandates since its founding, and this Phase III trial was an opportunity to tap into and strengthen Nepal’s research capabilities.
IVI strongly believes that building up research capacity is one of the most effective and sustainable avenues for advancing health and development in LMICs. Since the typhoid Phase III trial, Nepalese investigators, armed with this capacity, have executed a Phase III cholera vaccine trial and a Phase III trial of Sanofi’s COVID-19 vaccine – a great example of creating and building upon the capacity in a low/middle-income country.
In our increasingly globalized world, why do you believe that vaccination is crucial for global public health?
This quote from UN Secretary-General António Guterres has become the universally accepted mantra of the COVID-19 pandemic, and it’s very apt: “In an interconnected world, none of us is safe until all of us are.” In a pandemic setting, inequitable distribution of vaccines between high and low-income countries is a humanitarian crisis as well as a health and financial one.
Not only is vaccinating with equity a moral imperative, but uneven coverage also prolongs the pandemic and creates new variants in settings with uncontrolled outbreaks. The unprecedented speed at which the scientific community developed novel vaccines is truly remarkable, but it is ultimately vaccination that saves lives.
Image Credit: Rawpixel.com/Shutterstock
The International Vaccine Institute has a global impact, with project sites all over the world. In what parts of the world has the organization made the most impact thus far?
With headquarters in Seoul, Republic of Korea, and a new regional office in Stockholm, Sweden, IVI is currently engaged in over 20 field programs in 33 countries across Asia, Africa, and Latin America. Over the last decade, we’ve built up a robust disease surveillance network across sub-Saharan Africa to assess the burden of typhoid fever in the region, with the ultimate goal of introducing typhoid vaccination into routine immunization programs on the continent.
In Asia, particularly South and Southeast Asia, we have longstanding partnerships at every stage of vaccine clinical development for diseases such as typhoid, dengue, HPV, Hepatitis A and B, tuberculosis, COVID-19, and more.
Which age groups do you believe are most affected by vaccine-preventable diseases, and what can be done to improve vaccine coverage in these groups?
Infectious diseases affect all age groups, but many of IVI’s target disease areas profoundly affect young children. The most immediate barrier to vaccine coverage is lack of access due to limited availability, cost, health care infrastructure, and societal obstacles such as stigma and gender inequality. In other scenarios, there is insufficient demand for vaccines to necessitate the supply.
For instance, part of IVI’s work is to present the disease burden (through field epidemiology) and vaccine investment cases to governments. A core component of our oral cholera vaccine development program was collecting and presenting the evidence of disease burden to convince governments of the need to include cholera vaccines in routine immunization.
Beyond the discovery, development, and delivery of new and improved vaccines to cover younger age groups, vaccine advocacy and positive messaging from public health programs are crucial for increasing vaccine coverage.
Vaccine hesitancy is an issue in many countries globally. Such hesitancies are often the result of misinformation spread online or by word of mouth. How do you believe that we can increase vaccine confidence in those hesitant to get immunized?
In 2020, during an upswing of COVID-19 cases worldwide, the WHO released a report outlining key behavioral considerations for acceptance and uptake of COVID-19 vaccines. We can apply these considerations to increasing vaccine confidence for other life-saving vaccines. In addition to having the necessary knowledge, the report identifies three drivers for vaccine uptake: 1) an enabling environment 2) social influences 3) motivation. What may present as vaccine hesitance may actually be a response to the burdens, inconvenience, or stigma of getting vaccinated.
Increasing vaccine confidence requires removing physical barriers (costs, location, time, etc.); amplifying endorsements from key community figures; and communicating consistently, transparently, and proactively.
The theme of this year’s World Immunization Week is a “Long Life for All”. What does a “Long Life for All” look like to you and what role does immunization play in such a life?
Child deaths have decreased by more than 50% in the past 30 years, in large part due to vaccines in addition to other “WASH” initiatives including the availability of safe drinking water and hygienic facilities. I would also add that immunization ensures not only a longer life but potentially a more fulfilling and productive one. Immunization not only extends life spans but prevents disability and other factors that impact one’s ability to work and participate in society.
For instance, IVI is helping to develop two vaccines against schistosomiasis and chikungunya, two NTDs that may not have a mortality rate as high as other infectious diseases but disable children and adults for extended periods of time. This year’s theme of “Long Life for All” is very complementary with IVI’s vision of a world free of suffering from infectious diseases.
As a society, how can we work towards global vaccine equity and strive towards a “Long Life for All”?
The COVID-19 pandemic revealed our capacity to discover and develop novel vaccines at previously unthinkable speed and efficiency. Where we fell short is manufacturing these vaccines at scale and getting them to every corner of the world in an equitable manner. A concerted effort to commit to global vaccine equity will require an empowered, accountable global health leadership with the appropriate funding, tools, and personnel to enable, execute, and inspire multilateral action; and building national and regional capacities to develop vaccines, manufacture them, and license and distribute them.
What is next for the International Vaccine Institute, and what are your hopes for the future of vaccination?
2022 marks the 25th anniversary of IVI. This year, we’re looking forward to launching our first regional office in Stockholm, Sweden, which will significantly expand our network and research capacity in Europe and enable closer collaboration with our partners in Africa.
Several new member states joined IVI in the past couple of years, with two committing state funding, and we hope to engage with more governments and other global health stakeholders to multiply our impact.
WHO and Gavi, the Vaccine Alliance, note that full use of existing vaccines (i.e., complete vaccination) would save 2.5 million lives per year (not including COVID-19-associated deaths!). At the same time, infectious diseases for which no vaccines exist (HIV, TB, malaria, Group A Strep, non-typhoidal Salmonella, et al., kill 4-5 million per year). Put together, these statements summarize the future of vaccination: We must use the vaccines we have fully and equitably while adequately resourcing and prioritizing the development of vaccines for high-burden infectious diseases of poverty.
Ending Cholera 2030 Mozambique Cholera Prevention and Surveillance in Africa
Where can readers find more information?
About Jerome Kim M.D.
Jerome H. Kim, M.D., is the Director General of the International Vaccine Institute (IVI). He served as the Principal Deputy, MHRP as well as the Chief of the Laboratory of Molecular Virology and Pathogenesis and the Project Manager, HIV Vaccines Project Management Office, U.S. Army Medical Material Development Activity. He led the Army’s Phase III HIV vaccine trial (RV144), the first demonstration that an HIV vaccine could protect against infection.
He is an adjunct Professor of Medicine at the Uniformed Services University and an adjunct professor at Yonsei University Graduate School of Public Health.
Dr. Kim graduated from the Yale University School of Medicine in 1984 and completed his training in Internal Medicine and Infectious Diseases at Duke University Medical Center. He has authored over 300 publications and was recently awarded the Korean Medal of Honor for Civic Merit.
The mention sources can contact us to remove/changing this article
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- Indonesian leader says locked doors contributed to deaths
- The easiest and fastest way to get a flu shot
- China leads to table tennis team worlds knockout_china.org.cn
- PM Modi in Himachal; to inaugurate AIIMS Bilaspur
- Google chooses South Africa as its first cloud region TechCrunch
- Iran: A 5.7-magnitude earthquake occurred in West Azerbaijan Province at around 03:51 GMT on October 5
- Ford GT supercar bows with race-inspired LM Edition
- A psychedelic LSD-based drug relieves anxiety and depression in mice: Schott
- The Lord of the Rings: The Special Edition is coming to the US
- Nick Kyrgios sails on in Tokyo | ATP tour
- Indonesian President Joko Widodo orders an audit of the national stadium, while the FIFA boss offers help to solve the country’s football problems
- Watch the leading candidates in the Senate races go head-to-head in new ads