Health
Asthma drugs can block the important Sars-cov-2 protein, Iisc says | Bangalore News
Approved by US Food and Drug Administration A drug called (FDA), Montelukast, has been used for over 20 years and is usually prescribed to reduce inflammation caused by symptoms such as asthma, hay fever, and hives.
In a new study published at eLife, IISc researchers show that the drug binds strongly to one end (C-terminus) of the SARS-CoV-2 protein called Nsp1. “… this protein can bind to ribosomes (protein production mechanisms) in immune cells, stopping and weakening the synthesis of important proteins needed by the immune system, thus targeting Nsp1. Then you can reduce the damage caused by the virus, “said the IISc statement.
He states that the mutation rate of this protein, especially the C-terminal region, is very low compared to other viral proteins. Tanwheel Hussein, Associate Professor in the Department of Molecular Regeneration, Development and Genetics and Senior Author of Research. “Nsp1 is likely to remain almost unchanged in any variant of the virus that emerges, so drugs targeting this region are expected to act on all such mutants,” he added. ..
Hussain and his team first used computational modeling to screen over 1,600 FDA-approved drugs to find drugs that bind strongly to Nsp1. They nominated a dozen, including Montelukast and Saquinavir, as finalists.
“Molecular dynamics simulations generate a lot of data … and help us understand the stability of drug-binding protein molecules,” he said. Mohammad Afsar, Former project scientist at MRDG and now a postdoctoral fellow at the University of Texas. He is the first author of the study.
Hussein’s team, in collaboration with a group of Sandeep Eswarappa, an associate professor of biochemistry, cultivates human cells in a laboratory that specifically produces Nsp1 and treats them separately with Montercast and Saquinavir, with only Montercast. We have discovered that it can rescue the inhibition of protein synthesis. Nsp1.
“There are two aspects to consider, one is affinity and the other is stability,” Afsar said.This means that the drug not only binds strongly to the viral protein, but also needs to remain bound long enough.
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