Health
New report links PFAS to liver damage
To better understand how PFAS exposure is associated with liver damage, the authors of the new review examined evidence from 25 studies in humans and 86 studies in rodents. ..
“We have seen in isolated studies for years that PFAS can have toxic effects on the liver,” said a PhD student in the Department of Population and Public Health at Keck School of Medicine. , Says Elizabeth Costello, one of the leads. The author of the study. “Researchers have seen this in occupational health and safety surveys and population health surveys, but this review puts it all together in one place. This review includes several individual studies. Even if you can’t find a relationship, you can show that the evidence is pointing in the same direction. “
For people, the evidence clearly shows that exposure to a particular PFAS is associated with high levels of liver enzymes used as indicators of liver damage. This is also rising for people with NAFLD. The same association was found in animal studies, showing that rodents exposed to PFAS have abnormal fat accumulation in the liver.
To confirm that PFAS causes NAFLD directly in people, scientists will still need to do more research to track the subject over the years, Costello says. But the evidence so far strongly suggests that it is the case, Ducatman says. He says PFAS exposure can increase people’s susceptibility to NAFLD. Increased susceptibility combined with other risk factors such as a high-calorie diet and a sedentary lifestyle may help explain the increased condition.
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