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Routes to severe coronavirus in children discovered by scientists

Routes to severe coronavirus in children discovered by scientists

 


Researchers have discovered a pathway that is activated in severe cases of COVID-19 in children. This is an advance that can lead to early diagnosis and more targeted treatment of the disease. In this study, published in Nature Communications, various body parts such as the heart, lungs, and brain are inflamed, and the disease of children with COVID-19 presenting with multisystem inflammation syndrome, a type of acute respiratory distress syndrome. I have identified the mechanism. Lung disease.

The main trigger for severe COVID-19 in children was how blood clotting and immune system proteins responded to the virus, researchers say.

Conor McCafferty, a PhD student at the University of Melbourne, Australia, said:

“Our study was the first to reveal specific blood coagulation and immune protein pathways that affected children with COVID-19 who developed severe symptoms,” McCafferty said in a statement.

This study collected blood samples from 20 healthy children and from 33 SARS-CoV-2 infected children with multisystem inflammatory syndrome or acute respiratory distress syndrome.

Professor Damian Bonnett of the Greater Paris University Hospital in France, collecting samples to further explain the mechanism of these syndromes and establishing global partnerships is an important issue for improving treatment and outcomes. Said it was thought to be.

Studies have found that 85 and 52 proteins are specific for multisystem inflammatory syndrome and acute respiratory distress syndrome, respectively. Both syndromes are the major potential consequences of severe COVID-19.

According to the researchers, the data show that 1.7% of reported pediatric inpatients with COVID-19 included admission to the intensive care unit.

Children with COVID-19 who present with multisystem inflammatory syndrome also exhibit the same clinical features as toxic shock syndrome such as Kawasaki disease, fever, abdominal pain, vomiting, skin rash, and conjunctivitis, making it difficult to diagnose patients quickly. They said.

“This result provides an understanding of the less severe process of COVID-19 in children, which improves the development of diagnostic tests for early identification of at-risk children and the outcome of severe cases. “It helps to develop therapeutic targets for this,” said Professor Velai Gnyatovic of the Murdoch Children’s Research Institute (MCRI) in Australia.

“Understanding the mechanisms associated with severe COVID-19 in children and how the blood coagulation and immune system in children respond to the virus will help diagnose and detect acute COVID-19 cases and develop targeted therapies. Enables, “added Ignjatovic.

Sources

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2/ https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/pathways-to-severe-coronavirus-in-children-discovered-by-scientists/articleshow/91280958.cms

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