One of the XE cases confirmed in India, there are no reports of national clusters: INSACOG

According to a report from the SARS-CoV2 Genomics Sequencing Consortium (INSACOG) in India, cases of people infected with the XE variant have been confirmed in India. The location is still unknown.

INSACOG is a network of national testing laboratories established by the government. INSACOG said in its newsletter on April 18th and 25th that a case of XE was confirmed in the country.The person’s whereabouts are not yet known, and the Union Ministry of Public Health No statement has been issued on this issue yet.

In the latest bulletin, INSA COG said: Omicron (BA.2) is the dominant variety in India to this day. “12 states showed an increase in cases and 19 states showed a decrease compared to the previous week,” he added, adding that the suspicious recombinant sequence is under further analysis.

“BA.2.10 and BA.2.12 are the detected BA.2 substrains, and many older BA.2 sequences have been reclassified into these new substrains. So far, these substrains have been It has not been reported to be associated with increased severity of the disease, “the report said.

The INSACOG Bulletin details the distribution of the Variant of Concern (VoC), 4266 Alpha Mutant, 220 Beta, 3 Gamma, 43928 Delta, B.1.617 and B.1.617.3 5607, 20450 AY Series, 45359. Omicron, and one XE variant of a total of 119,834 samples sequenced.

Therefore, one case of XE has been confirmed in Japan.

According to experts, the XE subvariant has a 10% higher infection rate than the predominant BA.2 variant of Omicron, which caused the third wave in the country in January.

So far, there have been no reports of XE clusters across India.

BA.2.12.1, Omicron The sub-strains that are causing the increase in Covid-19 cases in the metropolitan area (NCR) have mutations in pesplomers that are similar to those found only in the Delta strain. It is clear whether this causes the severity of the infection, but so far clinicians have claimed that most Covid-19-positive cases are asymptomatic or mild.

Shahid Jameel, Senior Research Fellow at Green Templeton College, Oxford University, describes business standards as follows: Omicron Currently, there are two major strains, BA.1 and BA.2, both of which have several sub-strains. “As a group, BA.2 spreads about 20% better than BA.1,” he added, adding that the spikes in BA.2.12.1 have two important mutations.

“The BA.2.12.1 spike has two important mutations missing from BA.2.12 and other substrains. These are L452Q and S704L. Of these, they are similar (not identical). The mutant L452R is found only in the Delta lineage, “Jameel explained.

It is not yet known how the XE variant works with respect to the spread and extent of infection.

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