Health
Experimental oral covid pills show promising results for infection, infection
According to a study conducted in hamsters, the Covid vaccine in clinical trials designed to be taken as a pill neutralizes the SARS-CoV-2 virus in mucosal tissues such as the nose and lungs.
A study led by researchers at Duke University demonstrates the potential of a Covid vaccine to neutralize SARS-CoV-2 virus through mucosal tissue, limit infection, and limit the spread of active virus in suspended particles. Did.
“Given that most of the world is immune deficient, this is especially true for children. It is possible that a person vaccinated against a breakthrough infection will spread Covid to non-immunized family members and members of the community. It poses a public health risk, “says Stephanie N. .Langer, Postdoctoral Fellow of Varsity.
“There will be significant benefits to developing a vaccine that not only protects ourselves from illness, but also reduces infections to unvaccinated people,” Langer added.
The findings are published in the journal Science Translational Medicine.
Langel and his team (including vaccine developer Vaxart and a team from the clinical research non-profit Lovelace Biomedical Research Institute) test vaccine candidates using adenovirus as a vector to express the spike protein of the SARS-CoV-2 virus. Did. Human vaccines are designed to be taken as tablets.
In studies using hamsters, the vaccine elicited a strong antibody response in the blood and lungs.
When animals were exposed to high levels of SARS-CoV-2 virus and caused breakthrough infections, they were less symptomatic and had lower amounts of infectious virus in the nose and lungs than unvaccinated hamsters. Because of this, they did not release much of the virus through normal aerial exposure.
Unlike vaccines that are injected into the muscle, mucosal immunity increases the production of immunoglobulin A (IgA) in the nose and lungs, which is the first line of defense against pathogens in the immune system, Langer said.
These mucosal entrances are protected and the vaccinated person is less likely to be infected with the infectious virus when sneezing or coughing.
“Our data show that mucosal immunity is a viable strategy for reducing the spread of Covid due to airborne infections,” says Langel.
According to Langer, the study focuses on the original SARS-CoV-2 virus, and new studies are planned to test the vaccine against the Omicron mutant.
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