Health
Covid-19 severity in the elderly may be due to genetic reasons: Tribune India
Washington, May 9th
According to modeling studies, genetically pre-determined restrictions on the immune system may be key to why COVID-19 has such a devastating effect on the elderly.
Researchers at the University of Washington (UW) in the United States found that the ability of the immune system to fight COVID-19 depends heavily on immune cell replication, which, like other infectious diseases, is effective in destroying the SARS-CoV-2 virus. I pointed out that I am doing it. disease.
The study, recently published in The Lancet eBioMedicine Journal, suggests that the body’s ability to generate these cloned immune cells cannot be created indefinitely and is significantly reduced in old age. ..
“When DNA divides in cell division, the endcaps called telomeres get a little shorter with each division,” said Professor James Anderson, a modeler of the biological system at the University of Washington.
“After a series of cell replications, the cells become too short and stop further division. Not all cells or all animals have this limitation, but human immune cells have this cell. It has a lifetime, “Anderson said in a statement.
Despite this limitation, the average person’s immune system coasts fairly well until about 50 years of age, according to researchers.
It involves enough cell division to attack and eliminate the COVID-19 virus, which has the property that enough core immune cells, called T cells, shorten telomeres and rapidly reduce the number of immune cells. They said it was a time when they couldn’t clone themselves quickly.
According to Anderson, telomere length is inherited from parents.
These lengths make some differences between people of all ages, and also how old a person will be before these lengths are almost exhausted.
“Depending on your parents, your way of life, longevity, or, as our dissertation claims, your reaction to COVID-19 is your function when you were born,” he said. rice field.
To build the model, researchers used COVID-19 mortality data and telomere studies published by the US Centers for Disease Control and Prevention and the US Census Bureau. Much of this data has been published by co-authors over the last 20 years.
Gathering telomere length information about a person or a particular demographic may help doctors know who is less sensitive, the researchers said.
Physicians could allocate resources such as booster shots, which could make populations and individuals more susceptible to COVID-19, they added.
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