Fertility: Rat testis cells produce sperm after freezing for 23 years

To Claire Wilson

Rat testis cells frozen for 23 years produced sperm after being transplanted into mice.

Findings suggest that children who have frozen their testicle tissue prior to cancer treatment may be able to re-implant the tissue, so one day through in vitro fertilization (IVF) their biological child. to be able to hold something. Eoin Whelan At the University of Pennsylvania in Philadelphia.

Chemotherapy to treat cancer can kill the stem cells in the testicles that make sperm.Adults can have Frozen sperm samples prior to this treatmentHowever, it is not an option for children who have not yet experienced adolescence.

In such cases, some clinics expect to take a small sample of immature testicular tissue from the child, freeze it, and re-transplant it as an adult to mature and begin to produce sperm.At least one clinic in Belgium Approved to initiate such re-transplant surgery..

The work of Whelan and his colleagues shows optimism. They utilized rat stem cells that had been isolated and frozen 23 years ago, thawed and transplanted into the testis of mice.

Mice were treated with drugs that killed the cells that make their sperm. It was too toxic to be used in rats and had a defective immune system that prevented the transplant from being refused. For comparison, the same procedure was performed on other mice using rat cells that were removed and immediately transplanted, and rat cells that were frozen a few months ago.

Examination of the testes of mice revealed that 23-year-old stem cells survived and developed into a group of sperm-producing cells, which was about one-twentieth of the cell group of fresh or recently frozen tissue. A group of cells from 23-year-old implants produced mature sperm, each producing about one-third of what was obtained from fresh or recently frozen cell implants.

Nevertheless, if the same result happens to people, participants may produce some sperm, even in small numbers, Whelan says. “You really need only one viable sperm to succeed.”

There are some differences between the team’s method and the method currently used in fertility clinics, so it’s unclear if the results will be reflected in people, he says. Rod Mitchell At the University of Edinburgh, UK.

Researchers froze isolated testicular stem cells while the clinic frozen whole tissue samples. They also harvested cells from adult rats, but the clinic needs to harvest tissue from prepubertal children. “There are a lot of unknowns,” says Mitchell.

Journal reference: PLoS Biology, DOI: 10.1371 / journal.pbio.3001618

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