Connect with us


Family history should be taken into account in IBD screening

Family history should be taken into account in IBD screening


Family history of inflammatory bowel disease should be considered for disease screening programs, according to new data from the Swedish cohort.

A team led by Jonas F. Halfvarson, MD, Department of Gastroenterology, Faculty of Medicine and Health, Orebro University, estimated the prevalence of familial aggregation of IBD.

“The family history of IBD is a substitute for an individual’s genetic risk, in part an environmental risk of developing the disease, and has long been recognized as the strongest risk factor for IBD,” the author writes. I have. “Therefore, family history is routinely evaluated as part of a clinical work-up at the time of diagnosis.”

In the past, several studies have focused on IBD familial clustering. However, most of these studies are based on a smaller patient population that does not include controls.

Patient population

In a national case-control study, researchers compared IBD patients (n = 50,667) with controls (n = 506,720) between 2003 and 2017 and were first-degree relatives of IBD by age of diagnosis. I investigated the probability that there is. , Family history type, and IBD subtype. They also assessed future incidence of IBD in relatives of patients with IBD.

Of the IBD patients, 14,927 had Crohn’s disease, 27,221 had ulcerative colitis, and 8519 had unclassified IBD.

Each patient with IBD was identified from the Swedish national register.

The team used logistic regression to calculate the odds ratio as an estimate of the relative risk of IBD in first-degree relatives. They also estimated the incidence of IBD incident diagnosis in first-degree relatives of IBD patients and first-degree relatives of matching reference individuals from the general population as the number of events per 1000 person-years.

Risk of IBD

Researchers found that patients with IBD were mothers (3.0% vs 0.9%; OR, 3.5; 95% CI, 3.3–3.7) and fathers (2.9% vs 0.8%; OR, 3.5; 95% CI, 3.3–3.7). I found that I often have. ), Complete siblings (5.3% vs 1.5%; OR, 3.6; 95% CI, 3.4–3.8), and children with IBD (2.4% vs 0.9%; OR, 2.6; 95% CI, 2.4–2.8).

The strength of the overall association was directly related to the number of first-degree relatives affected. This strength also varied with IBD subtypes and age of diagnosis.

The highest odds ratios are for a subset of pediatric patients with Crohn’s disease (OR, 10.6; 95% CI, 8.2–13.5) and for pediatric-onset ulcerative colitis (OR, 8.4; 95% CI, 6.4–10.9).

The 10-year cumulative disease incidence for all siblings was 1.7% for all IBD patients, compared to 0.4% for all siblings.

“Variations in the intensity of familial IBD and future risks of IBD [first-degree relatives] We support differences in genetic predisposition and seek a targeted approach to potential screening programs, “the authors write.

the study, “Age Determines Risk of Familial Inflammatory Bowel Disease — National Study”Was published online Gastroenterological pharmacology and therapeutics..

Originally released under our sister brand, HCPLive..




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]