Family history of inflammatory bowel disease should be considered for disease screening programs, according to new data from the Swedish cohort.
A team led by Jonas F. Halfvarson, MD, Department of Gastroenterology, Faculty of Medicine and Health, Orebro University, estimated the prevalence of familial aggregation of IBD.
“The family history of IBD is a substitute for an individual’s genetic risk, in part an environmental risk of developing the disease, and has long been recognized as the strongest risk factor for IBD,” the author writes. I have. “Therefore, family history is routinely evaluated as part of a clinical work-up at the time of diagnosis.”
In the past, several studies have focused on IBD familial clustering. However, most of these studies are based on a smaller patient population that does not include controls.
In a national case-control study, researchers compared IBD patients (n = 50,667) with controls (n = 506,720) between 2003 and 2017 and were first-degree relatives of IBD by age of diagnosis. I investigated the probability that there is. , Family history type, and IBD subtype. They also assessed future incidence of IBD in relatives of patients with IBD.
Of the IBD patients, 14,927 had Crohn’s disease, 27,221 had ulcerative colitis, and 8519 had unclassified IBD.
Each patient with IBD was identified from the Swedish national register.
The team used logistic regression to calculate the odds ratio as an estimate of the relative risk of IBD in first-degree relatives. They also estimated the incidence of IBD incident diagnosis in first-degree relatives of IBD patients and first-degree relatives of matching reference individuals from the general population as the number of events per 1000 person-years.
Risk of IBD
Researchers found that patients with IBD were mothers (3.0% vs 0.9%; OR, 3.5; 95% CI, 3.3–3.7) and fathers (2.9% vs 0.8%; OR, 3.5; 95% CI, 3.3–3.7). I found that I often have. ), Complete siblings (5.3% vs 1.5%; OR, 3.6; 95% CI, 3.4–3.8), and children with IBD (2.4% vs 0.9%; OR, 2.6; 95% CI, 2.4–2.8).
The strength of the overall association was directly related to the number of first-degree relatives affected. This strength also varied with IBD subtypes and age of diagnosis.
The highest odds ratios are for a subset of pediatric patients with Crohn’s disease (OR, 10.6; 95% CI, 8.2–13.5) and for pediatric-onset ulcerative colitis (OR, 8.4; 95% CI, 6.4–10.9).
The 10-year cumulative disease incidence for all siblings was 1.7% for all IBD patients, compared to 0.4% for all siblings.
“Variations in the intensity of familial IBD and future risks of IBD [first-degree relatives] We support differences in genetic predisposition and seek a targeted approach to potential screening programs, “the authors write.
the study, “Age Determines Risk of Familial Inflammatory Bowel Disease — National Study”Was published online Gastroenterological pharmacology and therapeutics..
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