Studies have identified potential biomarkers for SIDS, but these are very early days.

SIDS usually occurs when the child is sleeping. Experts speculate that it is related to problems with the part of the baby’s brain that controls breathing and awakening. BChE is a cholinergic enzyme that is part of the autonomic nervous system and controls functions such as blood pressure and respiration. The authors of the study say more research is needed to determine if the BChE test can identify and prevent future SIDS cases.

Smoking during pregnancy is one of the risk factors for SIDS, along with family history and preterm birth. Researchers pointed out that animal studies have shown a link between indirect smoking and decreased BChE. However, many other changes during the first 6 months of life can also affect these enzymes and the general nervous system.

Dr. Carmel Harrington, an emeritus researcher at a children’s hospital in Westmead, Australia, who led the study, lost his child to SIDS 29 years ago. Sydney Children’s Hospital Network..

“Baby has a very powerful mechanism to tell you when you’re not happy. Usually, when you’re faced with a life-threatening situation, such as having difficulty breathing while sleeping because your baby is on your stomach, your baby Cries with excitement .. This study shows that some babies do not show this same strong arousal response, “Harrington told the network.

Harrington said the study showed that BChE was involved in this lack of arousal.

“Once we know that BChE is involved, we can start changing the results of these babies and make SIDS a thing of the past,” she said.

The findings do not reflect BChE activity in fresh blood, as the limitations of this study include blood samples that are more than two years old. Researchers also used coroner’s diagnosis rather than autopsy findings and included data on children aged 1 to 2 years, but SIDS is usually defined to include children under 1 year of age.

Dr. Rachel Moon, chair of the American Academy of Pediatrics’ Task Force on SIDS, noted the small sample size of the study and said the findings were not conclusive.

“The differences in blood levels of this enzyme were statistically different, but even if this was confirmed by a larger additional study, there was sufficient overlap in blood levels between cases and controls. It couldn’t be used as a blood test. This is a reasonable prediction. “

Dr. Gabrina DixonThe study is interesting, said the director of the Diversity of Academic Pediatrics at Children’s National in Washington. Studies need more numbers to say this is it. ”

First Candle, a national organization focused on eliminating sleep-related infant mortality and helping families, welcomed the study but cautioned.

“This is progress and needs to be optimistic for it, but it’s not the perfect answer,” CEO Alison Jacobson said in a statement. “Our concern about developing tests for vulnerabilities to SIDS is that parents have false reassurance and adopt unsafe sleep habits.”

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