Connect with us


Congenital giant nevus, which is often treated with disfiguring surgery, increases the risk of skin cancer. –ScienceDaily

Congenital giant nevus, which is often treated with disfiguring surgery, increases the risk of skin cancer.  –ScienceDaily


About 1 in 20,000 babies are born with what is called a congenital giant nevus. This is a huge pigmented mole that can cover most of the face and body. Due to the appearance of the mole and the risk of developing skin cancer later, many patients decide to undergo major surgery on their child to remove the entire lesion that can cause a large permanent scar. To do. Researchers led by researchers at Massachusetts General Hospital (MGH) recently created multiple preclinical models of this condition and used them to apply several medications to the skin to regress the lesion. We have shown that one topical drug can also protect against skin cancer.Their findings are published in the journal cell.

“The goal of our study is to develop a series of animal models designed to elucidate important biological features of these lesions, retreat nevus cells, and thereby the need for surgical treatment. The aim was to test non-surgical drug treatments for the skin with the aim of eliminating the “Senior Author, Director of the MGH Cancer Center’s Nevus Program and Director of the MGH’s Dermatological Biology Research Center.” David E. Fisher, MD, PhD said.

The model included mice designed to express a gene called NRAS This includes mice with mutations known to cause most congenital giant nevus in humans, and transplanted skin grafts containing human congenital giant nevus. Fisher and his colleagues used these models to analyze the different stages of these nevus and better understand how they form and develop.Also, when scientists use the model to test topical application of single or concomitant drugs that block signaling pathways known to be activated by. NRAS Mutations, they found that some of the treatments led to significant nevus regression. In addition, a drug that stimulates an inflammatory response after topical application to the skin completely regressed the nevus after three treatments. This treatment also provided complete prophylaxis against the formation of skin cancer in mice.

“These findings hope to prepare for additional improvements aimed at directly testing such skin treatments in patients with congenital giant nevus,” says Fisher. “This study includes additional studies of safety, potential for further enhancement of efficacy, and further analysis of the underlying mechanism. The overall goal is to prevent melanoma in these patients, It is to avoid the challenges of malformation phobia due to these lesions. “

Other research authors include Yeon Sook Choi, Tal H. Erlich, Max von Franque, Inbal Rachmin, Jessica L. Flesher, Erik B. Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S. Dobry, Mack. Su and Sharon are included. , Ezra Feder, Jose L. Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R. Zakka, Marjan Azin, Christin E. Burd, Norman E. Sharpless, X. Shirley Liu Clifford Meyer, William Gerald Austen, Jr. , Branko Bojovic, Curtis L. Cetrulo, Jr., Martin C. Mihm, Dave S. Hoon, Shadmehr Demehri, and Elena B. Hawryluk.

This work was supported by the National Institutes of Health, Dr. Miriam and the Sheldon G. Adelson Medical Research Foundation.

Story source:

material Provided by Massachusetts General Hospital.. Note: Content can be edited in style and length.




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]