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Congenital giant nevus, which is often treated with disfiguring surgery, increases the risk of skin cancer. –ScienceDaily

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About 1 in 20,000 babies are born with what is called a congenital giant nevus. This is a huge pigmented mole that can cover most of the face and body. Due to the appearance of the mole and the risk of developing skin cancer later, many patients decide to undergo major surgery on their child to remove the entire lesion that can cause a large permanent scar. To do. Researchers led by researchers at Massachusetts General Hospital (MGH) recently created multiple preclinical models of this condition and used them to apply several medications to the skin to regress the lesion. We have shown that one topical drug can also protect against skin cancer.Their findings are published in the journal cell.

“The goal of our study is to develop a series of animal models designed to elucidate important biological features of these lesions, retreat nevus cells, and thereby the need for surgical treatment. The aim was to test non-surgical drug treatments for the skin with the aim of eliminating the “Senior Author, Director of the MGH Cancer Center’s Nevus Program and Director of the MGH’s Dermatological Biology Research Center.” David E. Fisher, MD, PhD said.

The model included mice designed to express a gene called NRAS This includes mice with mutations known to cause most congenital giant nevus in humans, and transplanted skin grafts containing human congenital giant nevus. Fisher and his colleagues used these models to analyze the different stages of these nevus and better understand how they form and develop.Also, when scientists use the model to test topical application of single or concomitant drugs that block signaling pathways known to be activated by. NRAS Mutations, they found that some of the treatments led to significant nevus regression. In addition, a drug that stimulates an inflammatory response after topical application to the skin completely regressed the nevus after three treatments. This treatment also provided complete prophylaxis against the formation of skin cancer in mice.

“These findings hope to prepare for additional improvements aimed at directly testing such skin treatments in patients with congenital giant nevus,” says Fisher. “This study includes additional studies of safety, potential for further enhancement of efficacy, and further analysis of the underlying mechanism. The overall goal is to prevent melanoma in these patients, It is to avoid the challenges of malformation phobia due to these lesions. “

Other research authors include Yeon Sook Choi, Tal H. Erlich, Max von Franque, Inbal Rachmin, Jessica L. Flesher, Erik B. Schiferle, Yi Zhang, Marcello Pereira da Silva, Alva Jiang, Allison S. Dobry, Mack. Su and Sharon are included. , Ezra Feder, Jose L. Cortez, Suyeon Ryu, Tamar Babila Propp, Yedidyah Leo Samuels, Labib R. Zakka, Marjan Azin, Christin E. Burd, Norman E. Sharpless, X. Shirley Liu Clifford Meyer, William Gerald Austen, Jr. , Branko Bojovic, Curtis L. Cetrulo, Jr., Martin C. Mihm, Dave S. Hoon, Shadmehr Demehri, and Elena B. Hawryluk.

This work was supported by the National Institutes of Health, Dr. Miriam and the Sheldon G. Adelson Medical Research Foundation.

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