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PSA screening for prostate cancer, especially beneficial for black men

PSA screening for prostate cancer, especially beneficial for black men


The benefits of PSA screening for prostate cancer outweigh the harms of black men in particular, according to researchers who published the latest summary at the 2022 Annual Meeting of the American Urological Association. The results of the new analysis were published at the same time. New England Journal of Medicine..

Researchers have adopted two complementary methods to estimate overdiagnosis of prostate cancer in men aged 50-84 years between 1986 and 2016, a year before PSA screening became widespread. .. Percentage of prostate cancer in the screened and unscreened groups. They also used a model of the natural history of prostate cancer (PSA trajectory) to evaluate the effectiveness of various screening strategies.

For all races, researchers estimated 1.5-1.9 million overdiagnosis and 900-1.5 million prostate cancer overdiagnosis by 2016. Compared to 1986, the number of deaths from prostate cancer in men in 2016 was 270,000 less and the number of deaths in black men was 55,000 less.

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Researchers estimated that half of the 270,000 deaths from excess prostate cancer were due to PSA screening. To prevent death from one prostate cancer, the number required for diagnosis (NND) and treatment (NNT) will be 11-14 and 7-11 for all races, Jonathan E. Shoag, MD, University Hospital Reported by Reserve University School of Medicine and its colleagues in Cleveland Medical Center, Case Western Cleveland, Ohio. For black men, the estimates for NND (8-12) and NNT (5-9) were low.

“These data constitute strong support for prostate-specific antigen screening, especially in black men who lack evidence in clinical trials,” said Dr. Shoag and his team.

“Here we convincingly show that the screening trade-offs are very favorable and clarify that young healthy men in their 40s and 50s should at least undergo baseline PSA screening. “He said in a university hospital press release.

Investigators are policy makers Usefulness of PSA-based Prostate Cancer ScreeningEspecially for black men.

Subsequent reduction in prostate cancer incidence 2012 USPSTF Grade D Recommendations for Regular PSA Screening According to the team, do not consider the ratio of favorable risk to benefit. “Rather, the clear explanation of our findings is that mortality benefits have been incurred over the years, and the benefits to harm have been greater for black men than for the general public. That is. “

Disclosure: This study was partially supported by the Bristol Myers Squibb Foundation. See the original reference for a complete list of disclosures.


Basourakos SP, White R, Vince, Jr. RA, et al. Harm and Benefits of 30 Years of Prostate Cancer Screening in Black Men.. .. .. Announcement location: AUA 2022, May 13-16, 2022. Presentation LBA01-01.

Basourakos SP, White R, Vince, Jr. RA, et al. Harm and Benefits of 30 Years of Prostate Cancer Screening in Black Men.. N Engl J Med. Published online May 15, 2022. doi: 10.1056 / EVIDoa2200031

Researchers have found a favorable trade-off for PSA screening for prostate cancer [press release].. University Hospital; May 15, 2022.




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