Connect with us


Scientists report a complex mutation pattern for Omicron BA.2.




Evolution of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has diminished Effectiveness of Vaccines available. These vaccines Spike protein Of the ancestor SARS-CoV-2 that appeared in Wuhan, China in 2019.

study: Omicron BA.2 Complex Mutation Pattern: Avoiding Antibodies Without Losing Receptor Interactions.. Image Credit: Fit Ztudio / Shutterstock

Scientists have classified the newly emerging SARS-CoV-2 mutants as Variant of Concern (VOC), Variant of Concern (VOI), and Monitored Mutant (VBM). Researchers have said that for nsp14, a virus with a calibration mechanism, the high rate of mutation is surprising.


Studies have shown that SARS-CoV-2 VOCs are highly contagious, toxic, and can evade immune defenses induced by COVID-19 vaccination or spontaneous infection. To date, five VOCs have been identified: alpha, beta, gamma, delta, and omicron.

In most countries around the world, the Omicron subspecies has replaced the Delta subspecies and is the predominantly circulating strain. The World Health Organization has classified the Omicron variants into strain B.1.1.529 and subspecies BA.1, BA.1.1, BA.2, and BA.3. Currently, Omicron’s BA.2 substrain is predominantly circulating in many parts of the world. Previous studies have shown that this strain is more infectious than BA.1. Therefore, it is essential to understand why this strain is more contagious than other Omicron substrains.

the study

Recently, scientists have studied the mutation profile of BA.2 and analyzed the results based on their interaction with receptors and / or monoclonal antibodies.This study is available at International Journal of Molecular Science..

To study the mutation profile of BA.2, scientists analyzed a number of available sequences. This helped determine the BA.2 signature mutation. Furthermore, to evaluate the outcome of these mutations, the authors examined the structure of the spike receptor binding domain (S-RBD) of Wuhan (ancestor strain) and Omicron strains that complexed with monoclonal antibodies (mAbs). I analyzed it.

In this study, researchers identified mutations in BA.1 and BA.2 from sequences taken from the GISAID repository. These sequences were aligned using various sequence alignment programs such as MEGA X, MAFFT, and JalView to identify BA.2 signature mutations. Nextclade was used to measure amino acid changes and thereby identify BA.2 mutations. In this study, scientists considered mutations that were more than 50% prevalent as signature mutations.

Main survey results

In the current study, researchers analyzed the mutation profile of BA.2 and compared it to BA.1 (the original Omicron strain). They reported that there were significant differences in the number and distribution of mutations between the BA.2 and BA.1 omicron strains. Structural data show that BA.2 maintains significant contact with the host’s ACE2. This is the main invasion mode of the virus. In addition, this variant showed avoidance or reduced binding by neutralizing mAbs. Scientists have stated that the combination of these two factors makes BA.2 a surprising variant that can affect existing and future COVID-19 vaccination strategies.

Researchers have found that BA.2 retains the majority of BA.1 mutations, including mutations such as the delta variant G142D, which is involved in mAb avoidance or reduced binding capacity of them compared to the original strain. I reported that I got more. Current studies have revealed that BA.2 variants are evolving and contain specific mutations associated with S proteins and antibodies.

Determining the functions associated with BA.2 mutations in the ORF outside the region encoding the S protein was difficult. This is because the frequency of reported S protein structures is significantly higher than that of nsp structures. In addition, researchers structurally predict the role of mutations in proteins with multiple enzymatic functions (nsp3, nsp5, nsp12, nsp13, etc.) unless mutations occur in highly conserved active sites. Faced with difficulties.


The authors emphasized that one of the limitations of this study was that all sequences were taken from the GISAID repository to analyze the BA.1 and BA.2 mutations. These sequences had high coverage and quality, but some sequences contained gaps in different genes. This limited the identification of some mutations in a particular gene.

Scientists believe that new Omicron strains have emerged from unvaccinated or immune-protected individuals. In this study, the authors found that the BA.2 strain was a key mutation that not only reduced the effectiveness of the neutralized mAb, but also retained the same receptor-mediated invasion activity as the SARS-CoV-2 ancestral strain. Pointed out that is included.




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or [email protected]