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Research in Rats Offers Hope for New Parkinson’s Disease Treatment-Consumer Health News
Thursday, May 19, 2022 (HealthDay News)-Experimental stem cell replacement therapy for Parkinson’s disease is promising in rats and will soon be tested in human clinical trials, researchers say.
“We can’t get any more excited about the opportunity to help an individual in distress. [a] Although it is a genotype of Parkinson’s disease, the lessons learned from this trial also have a direct impact on patients suffering from sporadic or non-genotypes of the disease, “said Jeffrey Codewar, co-author of the study. I am. Disease Research Center at Arizona State University in Tempe.
Parkinson’s disease damages certain types of neurons in the brain, producing a chemical messenger called it. Dopamine..
The lack of dopamine causes not only psychological symptoms such as depression, anxiety, memory loss, hallucinations and dementia, but also physical symptoms such as stiffness and tremors.There is no cure to reverse or stop the progression of Parkinson’s diseaseMore than 10 million people are affected worldwide.
In the journal npj regenerative medicine, Researchers recently explained that adult blood cells are transformed into functional neurons that can settle in the brain and distribute dopamine.
Researchers have discovered one group of so-called pluripotency Stem cells (IPSC) worked well when transplanted into the rat brain, reversing symptoms such as Parkinson’s disease.
Researchers used iPSCs cultured for different periods of time, with 17-day cultures prior to differentiation into dopamine-producing neurons surviving more and longer distances than 24-day or 37-day cultures. I found it to be good at sending branches.
“It’s important, because they now need to grow long distances in the larger human brain, and we now know that these cells can do that,” Kordower said at the university. Said in the news release.
However, animal research is not always useful for human research.
the study We also found that the dose of iPS cells was important. Recovery was negligible in the few, but more nerve branching in the rat in the majority, completely reversing symptoms such as Parkinson’s disease.
Planned human clinical trials include patients with Parkinson’s disease who have a genetic mutation called a parkin mutation. These patients have the typical physical symptoms of Parkinson’s disease, but do not develop mental weakness or dementia.
If the treatment is effective, larger trials will follow.
The authors of the study said that this stem cell therapy could be combined with existing therapies to treat Parkinson’s disease, leading to the treatment of other neurodegenerative diseases.
“patient Huntington’s disease Also Multiple system atrophy or Alzheimer’s disease Certain aspects of the disease process can be treated in this way, “says Kordower.
For more information
For more information on Parkinson’s disease National Institute on Aging..
Source: Arizona State University, News Release, May 11, 2022
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