Health
Mouse recovery raises the hope that the drug can help people with SCI.Medical research
Mice with spinal cord injury showed remarkable recovery after receiving the drug originally developed for people with lung disease, the researchers said.
Seems to be about There are 2,500 new spinal cord injuries each year in the UKAs a result, some of the affected people lost their movement altogether. Despite many promising areas Of research Currently, damage to the spinal cord is irreversible..
Currently, researchers at the University of Birmingham have found that a drug called AZD1236, originally developed to treat chronic obstructive pulmonary disease in humans, is a type of spinal cord compression injury often associated with human motor accidents. States promising. It is also associated with symptoms such as osteoarthritis. A similar drug called AZD3342 showed comparable effects in rats.
Results published in the journal Clinical and Translational Medicine suggest that the drug blocks the action of enzymes known as MMP-9 and MMP-12, which are elevated after spinal cord injury. As a result, swelling of the spinal cord was reduced, levels of proteins associated with inflammation and pain were reduced, and the destruction of the blood-spinal barrier was limited. Scarring of connective tissue was also reduced.
The team found that mice treated with the drug for 3 days showed an 85% improvement in motor and sensory 6 weeks after spinal cord injury compared to injured mice not treated with AZD1236, but neurological function was intact. It was said that it was 80% of what was seen in mice. In addition, the benefits were similar whether the drug was given immediately after SCI or 24 hours later.
“What we’re doing is relieving damage to nervous tissue, so we’re conserving more and more neurons,” said the University of Birmingham, co-author of the study. Professor Zubair Ahmed of.
Ahmed added that the findings are exciting, adding that AZD1236 has already been shown to be safe in humans and may be able to participate in human trials sooner.
“In five to six years, if all goes well, this could be a potential cure,” he said.
Dr. Mariel Purcell, a spinal cord injury consultant who was not involved in the work, warns that the results have so far been limited to rodents and it is not yet clear if similar benefits will be seen in humans. However, we welcomed the findings.
“Spinal cord injury is a truly catastrophic, life-changing injury, and unfortunately there is little that can be done to limit the main consequences of injury such as paralysis and sensory impairment,” she said. “Introducing this intervention to newly injured patients seems to be very practical because the effect of AZD1236 is maintained and the treatment period is as short as 3 days without administration until 24 hours after the injury. It seems. It’s great to see such exciting results. “
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Sources 2/ https://www.theguardian.com/science/2022/may/20/recovery-of-mice-raises-hopes-drug-could-help-people-with-spinal-injuries The mention sources can contact us to remove/changing this article |
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