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First draft genomic sequence of monkeypox virus associated with outbreak

First draft genomic sequence of monkeypox virus associated with outbreak

 


In a recent study posted on Virological At the discussion forum, researchers unveiled a draft genomic sequence of the monkeypox virus associated with a recent outbreak in Portugal.

Study: First draft genomic sequence of monkeypox virus associated with suspected multilateral outbreak in May 2022 (confirmed case in Portugal). Image credit: cometa geo / Shutterstock
study: First draft genomic sequence of monkeypox virus associated with suspected multilateral outbreak in May 2022 (confirmed case in Portugal).. Image credit: cometa geo / Shutterstock

Background

Monkeypox is a rare disease caused by the monkeypox virus. It is a member of the same genus, including the smallpox virus that causes smallpox, the genus Orthopoxvirus of the Poxvirus family. Monkeypox is a zoonotic disease endemic to the rainforest regions of West and Central Africa and may be reported elsewhere. The disease was first identified in 1970 in a 9-year-old boy in the Democratic Republic of the Congo.

Enveloped monkeypox virus is a double-stranded (ds) deoxyribonucleic acid (DNA) virus with different rodents and non-human primates as hosts. The virus is classified into two different gene clades, one in West Africa and one in Central Africa (Congo Basin). Symptoms are less severe, but similar to those of smallpox patients. It spreads through direct contact with body fluids, lesions, contaminated surfaces / substances, or respiratory droplets.

In May 2022, multiple monkeypox outbreaks were reported in non-epidemic countries such as the United States (US), Portugal, Spain, the United Kingdom, Belgium and Sweden. Sequencing the viral genome helps to understand its epidemiology, transmission, and source of infection.

Research and results

In the current study, researchers have determined the genomic sequence of monkeypox virus from infected Portuguese men. A swab sample was obtained from a patient lesion on the skin on May 4, 2022.

The team used the QIA ampDNA blood kit to extract DNA from skin exudate.Prepared the library with a quick barcode sequence kit, followed by a shotgun Metagenomics The sequence was performed using the Oxford Nanopore MinION appliance. They used the “Inside FLU” (INSaFLU) web suite to map reads to reference sequences and manually inspect the sequences to validate the location of variants. Phylogenetic analysis was performed using new draft sequences containing publicly available genomic sequences.

Phylogenetic analysis revealed that the sequence belongs to a West African clade. They observed that the virus was most closely associated with the virus associated with previous exports from Nigeria in 2018 and 2019 to various countries. The draft sequence covers about 92% of the length of the reference sequence. The author reported that the draft sequence will be curated soon. With ongoing sequence data available from the Illumina platform, areas with low coverage, inserts / deletes (indels), or homopolymeric tracts will be refined.

Sources

1/ https://Google.com/

2/ https://www.news-medical.net/news/20220523/First-draft-genome-sequence-of-the-Monkeypox-virus-associated-with-major-outbreak.aspx

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