Health
Cell-based therapies show promise for type 1 diabetes: Tribune India
Toronto, May 23
Developed by a team of Canadian researchers, the Islet Cell Transplant Program is a safe, reliable, and life-changing treatment for people with difficult-to-control type 1 diabetes.
Pancreatic islets are a collection of cells that produce insulin. Insulin is a hormone that allows the body to control the flow of energy from food, store extras after meals, and release them to allow the body to function between meals.
In type 1 diabetes, patients need to take insulin by injection because the immune system accidentally destroys cells in the islets. Patients with difficult or “fragile” diabetes face long-term complications with life-threatening hypoglycemia or hyperglycemia.
James Shapiro, a professor of surgery at the University of Alberta, said: “This long-term safety data gives us confidence that we are doing the right thing.” “This data shows that cell-based therapies have meaningful and transformative impacts on diabetics.” It shows very strong evidence that it can be done, “added Peter Sr., director of the Alberta Diabetes Institute in Varsity.
“We offer something that is not possible with all other treatments for diabetes. It has unique comfort, predictability, and stability against blood glucose levels,” announced in The Lancet Diabetes & Endocrinology. In the study, researchers reported on 255 patients who received a total of more than 700 islet infusions at the university about patient survival, implant survival, insulin independence, and protection from life-threatening hypoglycemia. doing. From March 1999 to October 2019 at Alberta Hospital
The results showed that 70% of grafts survived at a median of almost 6 years, 79% of transplant recipients were able to stop insulin intake after two or more islet infusions, with a median of 95 days after the first transplant. I showed that. ..
Researchers reported that about 61% were insulin-independent after 1 year, 32% after 5 years, and 8% after 20 years. Most patients had to resume taking insulin injections, but usually the dose was much lower than the original requirement and diabetes control was good.
“The complete absence of insulin is not the main goal,” says Shapiro. “It’s obviously a big bonus, but the patient’s biggest goal is to be able to stabilize the patient’s life when it is incapacitated by violent and inadequate control of blood glucose and dangerous lows and highs. It’s transformative. “— IANS
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