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Genes related to survival after anthracycline, anti-HER2 therapy for breast cancer

Genes related to survival after anthracycline, anti-HER2 therapy for breast cancer

 



Disclosure: NIH endorsed the study. Zhu has not reported disclosure of relevant financial information. See Surveys for disclosure of relevant financial information for all other authors.


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Genetic variation UACA A gene that is an important regulator of the tumor suppressor Par-4 appeared to be associated with OS in patients receiving anthracyclines and HER2-targeted therapy. NPJ Breast cancer..

Rationale and method

“There are hundreds of genetic variations Related to breast cancer riskHowever, to date, few have been firmly associated with survival outcomes after breast cancer diagnosis. ” Qianqian Zhu, PhD, Associate Professor of Oncology in the Department of Biostatistics and Bioinformatics and co-director of Biostatistics and Statistics Genomics Resources at the Roswell Park Comprehensive Cancer Center told Healio.


Quoted from Qianqian Zhu, PhD.



The researchers conducted a multi-ethnic metagenomic-wide association study of OS in 3,973 patients. Breast cancer Included in pathway studies.

Main survey results

Result is, UACA Genes with OS in patients receiving Par-4 dependent chemotherapy at significant levels throughout the genome (P = 1.27 × 109). The researchers found four independent prospective breast cancer cohorts (total HR = 1.84; P = 1.28 × 1011 11).

In addition, the results of related studies across the transcriptome are higher. UACA Gene expression with poor OS (P = 4.68 × 107).

“These observations are biologically plausible and have been reproduced in a study of women with breast cancer in Shanghai,” Zhu said.

Implications

Genetic testing to identify mutations if findings are further reproduced in other breast cancer studies UACA Genes can support precision oncology goals for coordinating treatment for those who benefit most, Zhu said.

“Such tests allow clinicians to personalize their treatment plans by determining which patients best respond to anthracyclines or HER2-targeted therapies prior to the start of treatment,” Zhu added. rice field. “These findings also highlight the possibility of targeting both. UACA Genes and Par-4 pathways as a new approach to improving outcomes in breast cancer patients. “

Zhu et al. Plan to reproduce the findings in an additional cohort of breast cancer patients who have genetic information and treatment details.

“We are also looking at the biology behind our findings to learn more about the Par-4 pathway and how it interacts with these therapies,” she said. Told.

reference:

Researchers identify genes that predict treatment outcomes (press releases) in breast cancer patients. https://www.roswellpark.org/newsroom/202203-researchers-identify-gene-predicts-breast-cancer-patients-treatment-outcomes.. Published March 23, 2022. Accessed May 18, 2022.
Zhu Q, et al. NPJ breast cancer. 2022; doi: 10.1038 / s41523-022-00401-5.

For more information:

Qianqian Zhu, PhD, It can be reached at Roswell Park Comprehensive Cancer Center, 665 Elm Street, Buffalo, NY14203. email: [email protected].

Sources

1/ https://Google.com/

2/ https://www.healio.com/news/hematology-oncology/20220524/gene-linked-to-survival-after-anthracyclines-antiher2-therapies-for-breast-cancer

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