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Female Ear Reconstructed with 3D Printed Biological Tissue Implants | Medical Research
The woman reportedly reconstructed the outer ear using a 3D-printed biotissue implant, which appears to be the first trial of this type.
This technology MicrotiaA rare congenital disorder in which one or both outer ears are absent or incompletely formed.
according to New York TimesThe transplant was done in March in the United States to a 20-year-old woman from Mexico born with a small, malformed right ear.
The company behind the implant, 3DBio Therapeutics, publication Although reconstructed, detailed details of the implant and procedure were not available for immediate scrutiny.
According to the company, the implant consisted of a 3D-printed collagen hydrogel scaffold with the patient’s own chondrocytes. “The construct is printed in a size and shape that matches the patient’s contralateral ear for transplantation,” the press release said.
It is desired 11 patients According to the company, patients with unilateral microtia will be enrolled in clinical trials in Los Angeles, California and San Antonio, Texas, and the results will be published in medical journals.
Dr. Arturo Bonilla, the surgeon who performed the surgery, said: This study allows us to investigate the safety and aesthetic properties of this new procedure for ear reconstruction using the patient’s own chondrocytes. “
According to Bonilla, this approach incorporates more of the current techniques, including the reconstruction of the outer ear, including the removal of cartilage from the patient’s ribs, a more invasive procedure, or the use of porous polyethylene (PPE) implants. It can be replaced with a reconstructed ear using a new implant. flexible.
Although long-term follow-up of the recipient of the implant is required, Dr. Daniel Cohen, CEO of 3DBio, described the actual application of this technique as a “really historic moment.” He said he hopes the clinical trials have the potential to go beyond microtia.
“Our first indication focuses on cartilage in the field of reconstruction and orthopedics, including the treatment of complex nasal defects and degeneration of the spine,” he said. “We look forward to leveraging our platform to solve other unmet medical needs, such as reconstruction of breast mass resection, and eventually extend to organs. I am. “
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Professor Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine, who was not involved in the study, said that the cartilage of the outer ear injects sound into the middle and inner ear and controls the processing of sound. .. , And also cosmetically important.
According to Atara, this wasn’t the first time a tissue-engineered ear made of the patient’s own cells had been transplanted into a human.Implants made from such cells cultured on polymer scaffolds Previously reported in China..
However, Atara said: “This is an important advance in the field of regenerative medicine. 3D printing It aims to offer many advantages over handmade man-made structures, such as scale-up, higher design accuracy, and cost savings. “
Adam Periman, a professor of bioengineering at the University of Bristol and involved in the development of 3D cell printing technology, also welcomed the news. “Because the structure of the ear is cartilage and is bloodless- [in other words it has] No blood vessels – easier than bioprinting more complex tissue [or] Organs, it’s still a way to go, “he said. “That said, it’s an exciting prospect, as there are still few examples of tissue-engineered products and procedures.”
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Sources 2/ https://www.theguardian.com/science/2022/jun/02/womans-ear-rebuilt-with-3d-printed-living-tissue-implant The mention sources can contact us to remove/changing this article |
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