A large genetic study by the US Department of Veterans Affairs Million Veteran Program (MVP) found that a person’s height can affect some of the general health risks of adulthood. Important findings include the association between high and low risk of coronary heart disease, and the association between high and high risk of peripheral neuropathy and cardiovascular disease.
The results were published in the June 2, 2022 issue of the journal. PLOS Genetics..
Dr. Sridalan Ragavan of the VA Eastern Colorado Healthcare System, who led the study, described the results as “an important contribution to understanding how height is related to clinical status from an epidemiological point of view.” .. More research is needed before the findings can lead to changes in clinical care, says Raghavan. However, he explains, the results emphasize the link between height and clinical status, which affects the lives of veterans. “The broad scope of our study has resulted in a catalog of clinical conditions related to genetically predicted height. In other words, these relate to other environmental conditions that may affect height. No, height is a condition that can be a risk factor or a protective factor. Health. “
Height is usually not considered a risk factor for illness. However, past studies have shown that there is a correlation between someone’s height and the likelihood of experiencing many health conditions. What is not well understood is whether this correlation has a biological basis or is due to other factors.
How tall someone is as an adult is partly due to the genes inherited from their parents. However, environmental factors such as nutrition, socioeconomic status, and demographics (such as age and gender) also play a role in determining final height. This is why it can be difficult to determine the relationship between height and risk of illness.
To investigate this relationship, VA researchers looked at genetic and medical data from more than 280,000 veterans enrolled in the MVP. They compared these data with a list of 3,290 height-related gene mutations from recent genomic analyzes.
They found that the risk levels of 127 different medical conditions may be associated with the genetically predicted height of Caucasian patients. Black patients are less represented in genetic studies, so less data is available in this population. However, in this analysis, height-related medical features were largely consistent between black and white patients. About 21% of veterans in the MVP study were black. At least 48 of the links identified in white patients also applied to black patients. All of the most important findings, according to the researchers-; height is associated with a reduced risk of coronary heart disease and an increased risk of atrial fibrillation, peripheral neuropathy, and circulatory disorders-; with blacks Found in both white participants.
Overall, genetically predicted height was associated with both lower and higher risk of illness, depending on the condition. Being tall seems to protect people from cardiovascular problems. This study associated tallness with a low risk of high blood pressure, high cholesterol, and coronary heart disease. However, the risk of atrial fibrillation was higher in taller participants. These connections have been shown in previous studies.
Conversely, being tall may increase the risk of most of the non-cardiovascular conditions considered in the study. This was especially true for peripheral neuropathy and cardiovascular disease, including veins.
Peripheral neuropathy is damage to the nerves outside the brain and spinal cord, especially in the limbs. Previous studies have associated height with delayed nerve conduction and nerve problems. MVP studies confirm this link using genetic tools that suggest an increased risk of neuropathy in tall people.
Researchers have associated genetically predicted heights with conditions such as erectile dysfunction and urinary retention. Both of these are associated with neuropathy.
Raghavan called the findings on peripheral neuropathy “especially interesting.” He discussed this finding with a clinical colleague who often sees patients with peripheral neuropathy. Raghavan’s colleagues confirmed that tall people often show the worst neuropathy, but they were unaware of other studies explaining this link.
Symptoms such as cellulitis, skin abscess, chronic leg ulcer, and osteomyelitis were also associated with height. Being tall also seems to increase the risk of cardiovascular diseases such as varicose veins and thrombosis-; intravenous thrombosis.
Height can also increase the risk of neuropathy and other conditions not associated with circulation. Toe and foot deformities are conditions that can be caused by weight gain in tall people and are common in people genetically predicted to be tall.
The study also showed that height increases the risk of asthma and nonspecific neuropathy in women rather than men.
In summary, according to researchers, the results may be an invariant risk factor for some common conditions, especially those that affect the limbs, although height is not recognized but biologically important. It suggests that there is sex. They say that it may be useful to consider a person’s height when assessing risk and illness monitoring.
More work is needed before converting this study into clinical care, says Raghavan. “I think our findings are the first step towards a disease risk assessment in identifying conditions where height can really be a risk factor,” he explains. “In future work, we need to assess whether height can be incorporated into the disease risk assessment to inform strategies for modifying other risk factors for a particular condition.”
Future work will also focus on potential mechanisms that link height to these health conditions.
Researchers from several VA Healthcare Centers participated in this study. This includes, but is not limited to, Dr. Tim Asimes of the VA Palo Alto Healthcare System. Dr. Yangsan of the Atlanta VA Medical Center. Dr. Chris O’Donnell, one of the national leaders of MVP, previously belonged to the VA Boston Healthcare System and is now a member of Novartis.
MVP is a national research program to learn how genes, lifestyles, and military exposure affect health and illness. Since its launch in 2011, more than 885,000 veterans have participated in the MVP, making it one of the largest programs in the world on genetics and health.
Raghavan explains that such studies would not be possible without MVP.
MVP is very important for these types of studies. By linking clinical data with genetic data, it is possible to study clinical outcomes that are not commonly collected by other types of observational cohort data. For example, some of the stronger associations in our study-; peripheral neuropathy, venous insufficiency, osteomyelitis, foot ulcers and-; many other data, including genetics, are not collected on a regular basis. This collaboration will help bring research and findings back to clinical care. “
Dr. Sridalan Raggavan of VA Eastern Colorado Healthcare System
Not only is the MVP very large in number of participants, but it also enables previously impossible investigations due to the participation of various groups of veterans across the country. “Another important contribution of MVP is its diversity,” Raghavan explained. “The majority of participants are Caucasian, but there are many black and Hispanic participants who have been underestimated in genetic studies in the past.”
The mention sources can contact us to remove/changing this article
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- Why Microsoft’s $69 billion Activision deal is in London, not Washington
- Doubleheader Dub for Water Polo Featured by Upset Over No. 6Michigan
- Measles warning for NZ flight passengers after case discovery
- Paul Whelan’s brother describes the harsh conditions his brother faces in a Russian prison
- UK family to apologize in Grenada for slave past – BBC News
- World Cancer Day: Closing the Care Gap
- ‘Absurd’: Cupp reacts to GOP criticism of Biden over alleged spy balloons
- Post-Game Notes – Arizona vs. USC
- Instagram reportedly working on paid verification subscriptions like Twitter Blue
- Third quarter run not enough for K-State on Sunday
- Stock Market News, Economic & Financial News, Sensex, Nifty, Global Markets, NSE, BSE Live IPO News
- Bears have solid performances at Penn State Sykes and Saock Challenge