Health
Truncated tau protein may lead to better diagnosis and treatment of Alzheimer’s disease: research
Scientists at the University of California, San Francisco, say that a relatively unstudied form of tau protein associated with neurodegenerative disease may be a better way to diagnose and treat diseases like Alzheimer’s disease. I found. The results of this study were published in Neuropathology and Applied Neurobology.
According to scientists, the shape of the tau, which breaks down into fragments that accumulate in the brain of people with Alzheimer’s disease, may be responsible for the degenerative progression associated with this condition. However, this is different from the accumulation of other tau, which was the focus of previous drug development.
“This study opens our eyes to a key pathogenic process of Alzheimer’s disease that has received less attention,” said neuropathologist Dr. Lee T. Grinberg. Pharmaceutical chemistry.
Greenberg said that the “huge” number of neurons in the toxic entanglement of accumulated tau contained these tau fragments. Researchers have long known that another type of tau, called phosphotau, is reportedly present in neurons affected by Alzheimer’s disease. However, efforts to target this type of tau with drugs have not been successful so far.
Meanwhile, scientists have been able to assess human brain tau, thanks to UCSF’s Neurodegenerative Disease Brain Bank. While conducting the study, researchers observed tissues donated by 37 patients, while others in some patients with Alzheimer’s disease had neurons of both types. The patient was found to have only fragmented tau.
In addition, the fragmented tau abundance observed in patients with Alzheimer’s and Pick disease was rarely seen in patients with other forms of dementia with abnormal tau function, Grimberg said. rice field. This is not easy now.
Researchers also hope that this study will give better ideas on how these drugs can be used to treat Alzheimer’s disease, develop better diagnostic tests, and identify other neurodegenerative diseases. I made it clear.
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