Health
Cancer disappears in all patients during small clinical trials, researchers say
((((WJW) – small Cancer test It has achieved remarkable results. Everyone in the trial (14 so far) is in complete remission.
Doctor-led trial in New York Memorial Sloan Kettering Cancer Center He studied the treatment of patients with rectal cancer who took dostalimab, a monoclonal antibody designed to fight the disease, and the results were recently published. New England Journal of Medicine..
According to the report, 14 patients who all had tumors with specific gene mutations are now in remission. press release From the cancer center.
MSK clinical trials were investigating whether immunotherapy alone could defeat rectal cancer that had not spread to other tissues.
Researchers have explained that cancer cells can confuse immune cells and avoid attacks. This allows the tumor to hide and grow. Immunotherapy with drugs like Dostar Limab helps immune cells detect and attack those cancer cells. Dosallimab has previously been used to treat cancer of the endometrium.
“Immunotherapy shrank the tumor much faster than I expected,” Dr. Andrea Sersec said in the release. “My research nurse, Jenna Sinopoli, said,” The patient has only received one treatment, is no longer bleeding, and is no longer in severe pain. ” ”
The patient reported feeling normal again after only a few treatments, Cerkek said.
“A young man and his family were just sitting in a stunned silence when I told them that his cancer had disappeared,” she added. “Then they thanked us many times.”
After immunotherapy, each patient received the same news: their rectal cancer disappeared. No patients needed standard treatment with radiation therapy, surgery, or chemotherapy, and all patients had not had cancer for up to two years, the researchers said. Reported this week..
So what’s next? MSK is looking for more patients to enroll in clinical trials.
Participants in the MSK study have stage 2 or 3 rectal tumors with specific genetic makeup: mismatch repair defects (MMRd) or microsatellite instability (MSI). It is believed that 5% to 10% of all patients with rectal cancer have MMRd tumors. According to MSK, 45,000 Americans are diagnosed with rectal cancer each year.
“Our message is to test for rectal cancer to see if the tumor is MMRd,” said study co-author Dr. Luis Diaz. I am saying. Sunday release.. “There are trials that may help you with MSK, regardless of the stage of the cancer.”
Dr. Diaz says he wants to be “the tip of the iceberg” in the fight against cancer. He added that they “currently enroll patients with cancer of the stomach (stomach), prostate, and pancreas.”
You can find more details about the study hereAnd the full text of the study can be found at New England Journal of Medicine..
WXIN’s Matt Adams contributed to this report.
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