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Small-scale anticancer trials have confirmed that tumors disappear in 100% of patients | Health

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Small-scale clinical trials are affecting the world of oncology with earthquakes. Six months after treatment, the tumor disappeared in all 14 patients diagnosed with early-stage rectal cancer who had completed the study by the time it was published.

Researchers in the field of colorectal cancer welcome the study published in the New England Journal of Medicine on Sunday as a breakthrough development that may lead to new treatments for other cancers.

Andrea Selsek, an oncology scholar and lead author of the study at the Memorial Sloan Kettering Cancer Center in New York, said:

All patients shared the same genetic instability with rectal cancer and had not yet been treated. Each was given 9 doses of intravenous dosterlimab. It is a relatively new drug designed to block certain cancer cell proteins that, when expressed, can suppress the immune system’s response to the fight against cancer.

Six months later, a scan that once showed a discolored tumor with nodules revealed a smooth pink tissue instead. No evidence of cancer was detected by scanning, biopsy, or physical examination.

“All 14 patients? Very low probability in oncology, and in fact unprecedented,” Cercek said.

The results were so successful that none of the 14 patients who completed the study required planned follow-up treatment with chemoradiation therapy or surgery and had no significant drug complications. The other four patients in the trial are still being treated, but have shown the same promising results so far.

Sascha Roth, the first patient to participate in an study in late 2019, knows directly how big the results are, but she and her family have had a wider impact since the news was released on Sunday. Said that he was beginning to understand.

“My cousin from Brussels said it was on the paper there,” Ross said on Tuesday. “I’m touching everyone.”

This result represents a promising option for treating rectal cancer and can often have life-changing effects on patients.

Rectal cancer has a higher survival rate when treated early, but the most effective conventional treatments for radiation, chemotherapy, and surgery are permanent bowel and bladder dysfunction and sexual dysfunction in patients. , And may leave infertility. For young women, treatment can cause scarring of the uterus and prevent pregnancy. Other patients with low rectal tumors should use an artificial anal bag permanently after surgery.

There are some caveats to this study. Patient sample sizes varied in age, race, and ethnicity, but were small. And even early-stage patients in the trial have several more years of observation to make sure that the tumor has not reappeared or metastasized elsewhere in the body. This result also results in people who have certain abnormalities in rectal cancer, known as mismatch repair deficiencies, which interfere with the body’s ability to normalize or “repair” abnormalities when cells divide and instead cause mutations. Only relevant. Deficiency occurs in about 5% to 10% of all patients with rectal cancer and tends to resist chemotherapy.

“We are definitely seeing an influx of people saying,’Is this medicine for me?'” Cercek said. “It’s a very emotional reaction.’Oh, they have cancer and are looking at them now.'”

David Ryan, director of clinical oncology at Massachusetts General Hospital, said the results were groundbreaking for cancer patients with mismatch repair deficiency. The study was sponsored by Tesaro, a biotechnology company acquired by GlaxoSmithKline when the earliest patients began treatment in 2019.

“This is a huge problem,” said Ryan, who did not participate in the study. “It would be really hard not to think about this for the next patient going through the door:” Should I do chemotherapy and radiation therapy, or should I do this immunotherapy? “”

Ryan said that study participants have been and will continue to be monitored by a team of experts who can monitor, spread, and promptly intervene in treatment as needed. I am saying. He said the need could be a challenge for patients who do not live near places with easy and regular access to professional care.

“I’m worried that if a recurrence occurs, I’ll have to pick them up as soon as possible to give people the best chance,” he said.

However, Ryan and Celsec are separate, and the test results show that anyone with mismatch repair deficiency in other tumor types such as pancreas, stomach, and bladder can be effectively treated with the same drug from the Celsec study. Said to cause.

For Ryan, this study also emphasizes the importance of cancer patients who are aware of mismatch repair status.

“We always knew that, but we didn’t know that these were tumor types that responded to immunotherapy like gangsters, and that the tumors melted like butter in treatment,” he said. I did.

Cercek presented his paper at the American Society of Clinical Oncology’s annual meeting in Chicago on Sunday morning. She hadn’t finished her 10-minute presentation when her room was applauded. Gasping and tears when bold, white underlined letters appeared on the blue screen, along with the top-line discovery of her study, “100% clinical complete response in the first 14 consecutive patients.” It spread to the audience.

In layman’s terms, it was like spiked football after a touchdown.

Ross, now 41, has won as well. She described her journey to trial as “strange.”

“All the stars were aligned in the perfect way that allowed me to do this test,” she said. “If I had a single dose of chemotherapy, it would have disqualified me.”

Ross, who lives in Bethesda, Maryland and runs a furniture store, was diagnosed in September 2019 at the age of 38. She experienced some rectal bleeding and chalked it on the anti-inflammatory drugs she took as a result of her active lifestyle, including occasional bicycle and soccer collisions.

“I thought they would tell me I had a gluten allergy,” Ross said. “I definitely didn’t expect a diagnosis of cancer.”

She advised a friend who was diagnosed with colorectal cancer a year and a half ago about memorial sloan kettering or bust. She met her MSK doctor three days before she planned to start chemotherapy in the Washington area. The doctor remembered “throwing a gauntlet” in her office.

“He said,’You are not a candidate for surgery because of where the cancer is,'” he advised her, and because she had an abnormality in the cancer, chemotherapy (usually). Advised that (standard of care) would not be an effective option. It tends to resist the treatment.

Doctors were almost certain that she was a “lynch” patient, or a person with hereditary cancer syndrome associated with an abnormality. Ross’s doctor introduced her to Selsec, who soon became the first patient on her trial.

Roth had to wait another two months for FDA approval before starting treatment.

“In my mind, every day it goes by, I’m crazy with my eyes rounded,” she said about the fear that her cancer might worsen from stage 3 to stage 4 while waiting. Told. “But I was relieved that the cancer wouldn’t grow in a day.”

Ross was closely monitored to make sure it was safe to wait for treatment and keep her on trial. She started her treatment in December 2019. After her first infusion, she went to Florida on vacation and she said she didn’t feel any harmful side effects. She also kept running.

During the trial, Ross’s tumor was visibly shrinking. Six months after Roth moved to chemotherapy, she was called by Cercek late Friday night and instructed to cancel her move to New York. The researchers were trying to coordinate the exam. Chemotherapy does not need to be combined with radiation therapy or surgery, at least for now.

Ross’s family jokes that she is a “unicorn” and a living example of a medical miracle. Her Ross feels her gratitude to her doctors and nurses, and to those who have defended herself and encouraged her to seek her second opinion.

She is also grateful for advances in science given the prevalence of cancer in her family. Ross’s father died of a brain tumor in 1999, and her mother is now fighting cancer “on the last days of her life.” Thanks to her innovations in this area, she feels optimistic about her future.

“I feel universal gratitude, but I also have hope for others,” she said. “I hope all the cancers.”

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