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Intrauterine COVID exposure associated with neurodevelopmental disorders


June 10, 2022-New studies suggest that infants exposed to SARS-CoV-2 in utero are at increased risk of neurodevelopmental disorders in the first year of life.

However, it is unclear whether it is the exposure to the pandemic or the mother’s exposure to the virus itself that can harm neurodevelopment in early childhood.

“In this analysis of 222 offspring of mothers infected with SARS-CoV-2, neurodevelopment compared to the offspring of 7550 mothers in the control group (uninfected) who gave birth during the same period. Diagnosis has been observed to be significantly more common among exposed offspring, especially those exposed to maternal infections in late pregnancy, “they write.

The research is Published online June 9th JAMA network open..

Voice and language disorders

This study included 7772 predominantly singleton births at six hospitals in Massachusetts from March to September 2020 and was confirmed by a polymerase chain reaction (PCR) test during pregnancy. -2 Includes the birth of 222 (2.9%) of infected mothers.

In total, 14 (6.3%) of the 222 children born to SARS-CoV-2 infected mothers were diagnosed with neurodevelopmental disorders in the first year of life, compared with 7550 unexposed offspring. Of these, 227 (3%).

Taking into account factors such as preterm birth, race, ethnicity, insurance status, child gender, and mother, infants exposed to COVID are significantly more likely to undergo a neurodevelopment diagnosis in the first year of life. ..

The association with neurodevelopmental disorders was even greater with the third trimester SARS-CoV-2 infection.

Most of these diagnoses reflect motor or language and language and language developmental disorders.

Researchers found a link between prenatal SARS-CoV-2 exposure and neurodevelopmental diagnosis at 12 months, linking maternal viral infections and maternal immune responses to infant neurodevelopmental disorders. It states that it is consistent with the literature. ..

However, they may find that children born to women infected with the first wave of the pandemic have not reached the second wave, between prenatal SARS-CoV-2 exposure and the harmful neurological development of the baby. It is not yet known if there is a decisive relationship with. Birthday — When neurodevelopmental disorders such as autism are usually diagnosed.

Infected mothers who become ill during pregnancy tend to seek medical evaluation, and clinicians tend to refer them for diagnosis or evaluation, which can also bias the findings.

Nonetheless, the findings support the results of studies published in a similar study just presented at the 2022 Conference of the European Psychiatric Association. These results also showed an association between maternal SARS-CoV-2 infection and neurodevelopmental disorders in 6-week-old infants.

“Questions remain”

and Accompanying commentaryTorri D. Metz, MD, MS of the University of Utah Health in Salt Lake City, said the preliminary findings of Perlis and colleagues are “very important, but many questions remain.”

“Essence, everything we know now is In utero Maternal exposure to SARS-CoV-2 infection is from children exposed to early and alpha variants of SARS-CoV-2. These are only children of sufficient age to undergo a rigorous neurodevelopmental assessment, “Mets points out.

Finally, Mr. Mets said that he was a pandemic. In utero Maternal exposure to SARS-CoV-2 infection can adversely affect the outcome of infant neurodevelopment.

However, this type of study only covers historical data, so it can only show relevance, not causality.

“This type of work is aimed at generating hypotheses, and that goal has been achieved because these preliminary findings generate a number of additional research questions to investigate,” Mets said. I am writing.

Among them: Is there a genetic predisposition to adverse consequences? Are different effects observed depending on the SARS-CoV-2 mutant infected by the mother, the severity of the infection, and the trimester of the infection? Was it the virus itself or all social changes that occurred during this period, including differences in the experience of changes with and without SARS-CoV-2?

“Probably the most important issue is how to intervene to mitigate the negative effects of a pandemic on young children,” Mets said.

“To examine these findings, extract some of the nuances, and identify the ones at greatest risk,” she adds, the need for studies to track and observe mothers for a period of time.




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