Health
Fentanyl can cause behavior-like changes in young mice, such as autism
Fentanyl, a muopioid receptor agonist, is one of the most commonly used analgesics in hospitals and can cause long-term behavioral and somatosensory disorders in rodents. However, it is unclear whether the use of fentanyl is associated with the development of autism.Animal research led by researchers at Massachusetts General Hospital (MGH), Shanghai 10th The People’s Hospital and the University of Pennsylvania have shown that fentanyl can cause behavior-like changes in young male and female mice, such as autism. The survey results are British Journal of Anesthesia Science..
Studies by other groups have shown that dysfunction of the N-methyl-D-aspartate receptor contributes to autism.Variations Grin2a When Grin2b, The gene encoding the GluN2A and GluN2B subunits of the N-methyl-D-aspartate receptor is associated with autism. In addition, the anterior cingulate cortex of the brain is affected by autism.
In this current study, the research team reported that fentanyl induces autism-like behavior in young male and female mice by activating muopioid receptors in the anterior cingulate cortex.Moreover, these fentanyl-induced autism-like behaviors were partially mediated by hypermethylation. Grin2b Expression in the anterior cingulate cortex of mice.
Because the anterior cingulate cortex is the hub that mediates social information, we Grin2b In that area.Fentanyl Grin2b In the anterior cingulate cortex.Overexpression Grin2b Prevents behaviors such as fentanyl-induced autism in mice. These findings suggest potential mechanisms for preventing or treating behaviors such as autism. “
Yuan Shen, MD, PhD, lead author and professor of thesis Psychiatry 10 in shanghaith People’s Hospital
This group conducted experiments using an open field test (mouse can walk in a box) and an elevated cross labyrinth (mouse can walk on an elevated platform), and mouse anxiety and stereo. Detected a type of behavior. A three-chamber social preference test (where one mouse can interact with another mouse) was also used to assess potential social defects. “We used these tests because impaired social interaction, stereotypical behavior, and anxiety are important features of behavior such as autism in mice,” said Zhihao Sheng, co-lead author of the paper. Says.Shen is a graduate student in Shanghai 10th People’s hospital.
“But the changes in mice in these behavioral tests are not the same as in human autism, because these behavioral tests can show certain characteristics of behavioral changes similar to the symptoms of autism. It is only used to study autism-like behavior in mice, “said Dr. Qidong Liu, co-lead author and assistant professor of Shanghai 10.th People’s hospital.
Co-authors Zhongcong Xie, MD and PhD add: The results will facilitate further studies, including clinical studies, to determine the potential neurobehavioral effects of opioids on brain development. Xie is Director of Basic Science Research in MGH Anesthesiology, Critical Care and Pain Medicine, and Professor of Anesthesiology Henry K. Beecher, Harvard Medical School.
Other authors include Changhai 10’s Chun Cheng and Mengzhu Li.th People’s Hospital and Shanghai First Obstetrics and Gynecology Hospital, W. Andrew Kofke of the University of Pennsylvania, and Jed Barash, a neurologist in Massachusetts.
This research was supported by the Ministry of Science and Technology of China and the National Natural Science Foundation of China.
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Journal reference:
Shen, Z. , et al. (2022) Fentanyl induces autism-like behavior in mice by hypermethylation of the glutamate receptor gene Grin2b. British Journal of Anesthesia Science. doi.org/10.1016/j.bja.2022.04.027..
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