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Scientists have discovered that “anti-hunger” molecules are formed after exercise.News center

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In search of an answer, they turned to racehorses. Li and Long called Golden Gate Fields, a racehorse in the Bay Area, to ask if they could get a blood sample of a racehorse. Racehorses, like human athletes, are often tested for fortifiers, Truck Veterinarians Long said. Getting a blood sample from a racehorse would be easy. When Long and his team performed the same mass spectrometric experiments, the results again showed spikes of post-exercise mystery molecules with a mass of 236. ..

It happens to be a long colleague Michael Snyder, PhD, Professor and Chair of Genetics, and Stanford W. Asherman, MD, Professor FACS of Genetics, MD recently published the results of a study analyzing the molecular effects of movement on the human body. It was found that Snyder was also measuring molecules that popped out during and after exercise. As you may not know, there was one prominent peak.

“I emailed the project postdoc,” Listen, we’re looking for this molecule with a mass of 236. Do you know if this is in your data? “Long said. rice field. “A few hours later, I get a reply,” I can’t believe it. ” But in reality, this molecule was one of the top three hits in the entire dataset. Another good luck: Snyder’s team just decoded the chemical formula of the molecule and helped the team decipher that it was a combination of lactic acid and phenylalanine.

It’s solved: Lac-phe decides to nosh Cabosh for mice, and perhaps for racehorses and humans. But how? Lactic acid is a molecule that creates a burning sensation when looking for the last person, and increases in the body when exercising. The spike causes a bond between lactic acid and phenylalanine.

Interfere with hangering

This study showed that the binding of lactic acid to phenylalanine is catalyzed by a protein called CNDP2, which has high levels of activity in other cells, including immune cells and skin cells. “That is, when we exercise, different types of immune cells sense lactate and CNDP2 helps produce lac-phe,” says Long. Mice lacking CNDP2 were unable to produce lac-phe after exercise, ate more and packed more fat than mice with normal CNDP2 activity.

“We estimate that the lac-phe pathway is involved in about 25% of the anti-obesity effect of exercise,” Long said.

Long and his team also showed that when lac-phe was given to obese mice, the mice were not hungry and quit a high-calorie diet. “I saw their food intake suppressed by about 30%,” Long said. “It led to weight loss, fat loss, and improved glucose tolerance, indicating a reversal of diabetes.”

“We thought,’Wow, all this evidence really suggests that lac-phe goes to the brain to suppress feeding,'” Long said.

Before we all start looking for lac-phe on drugstore shelves, Long digs deeper into the mechanism of how lac-phe suppresses hunger signals, although this finding is exciting. I warn you that this is just the beginning of a series of studies. It also means focusing on which receptors in the brain’s lac-phe are targeted. He said that was their next step.

Researchers at the University of California, Berkeley, the University of California, Davis, the University of Birmingham, the University of Copenhagen, the University of Radbaud, and the University of Thomas Jefferson also contributed to this study.

This study was funded by the National Institutes of Health (Grants DK124265, DK113954, DK115761, DK117281, DK120858, GM113854), Ono Pharmaceutical, US Department of Agriculture, American Heart Association, and Novonordisk Foundation.

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2/ https://med.stanford.edu/news/all-news/2022/06/anti-hunger-molecule-exercise.html

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