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Can this blood test measure how the immune system responds to Covid-19?

Can this blood test measure how the immune system responds to Covid-19?

 


A newly developed blood test that measures the body’s T-cell immune response to SARS-CoV-2 may give individuals a “comprehensive picture” of immune defense against the virus, Denise Chow reports to NBC News. doing.

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Details of the study and main findings

according to study Published on Monday Nature biotechnologyA new test developed by researchers in Mount Sinai And that Duke-NUS Medical College In Singapore, immunity is measured by looking at parts of the immune system that boost long-term immunity to help the body “remember” the virus.

To measure a person’s immunity, researchers took a small blood sample and mixed it with a piece of coronavirus protein. Next, I examined the sample to see if the T cells were activated. T cells can “remember” traces of the virus from vaccinations and infections. This means that this test can measure immunity protected from one or more Covid-19 infections, or vaccinations or booster shots.

This test “may help us understand the complex entanglement of Covid immunity that currently exists from person to person,” Chow writes.

According to Ernesto Guccione, one of the authors of the study and an associate professor of oncology and pharmacology. Tisch Cancer Institute At Mount Sinai, immunocompromised individuals who may have difficulty producing immunity from vaccination can use this test to measure their response to the vaccine and assess their vulnerability.

“Ideally, it will give you a big picture of where you are standing and a comprehensive picture of your immune protection,” Guccione said.

Previous studies have suggested that T cells can recognize all known and concerned variants, including Omicron, but Guccione states that scientists are still actively studying this finding. rice field. They continue to improve their tests and study how well T cells respond to different mutants.

“The data released so far are very promising,” he said. “Fortunately, immunity to multiple proteins from the virus is well developed, many of which are not prone to mutation by mutants.”

Researchers are focused on clinical trials and want to get approval from both FDA And that European Medicines Agency..

Commentary

Previously, tests to detect T cells were mainly used in the laboratory. This is mainly because the process is expensive and difficult to run on a large scale. However, he added, this new test kit is designed for widespread use and results are usually available within 24 hours.

In addition, running each test costs about $ 50. However, Jordi Ochando is a co-author of the study and an assistant professor of oncology. Mount Sinai School of Medicine At Mount Sinai, he said product licensed companies could change prices.

Guccione acknowledged that more research was needed, but said the overall accuracy of the test results was comparable to similar tests performed in the laboratory.

Currently, this test can identify T cell activation, but researchers hope that future versions of the test may provide more detailed information.

For example, future versions of the test may be able to provide details about the size and duration of an individual’s immunity to the coronavirus.

“We haven’t reached that level yet to determine the degree of T cell immunity intensity and correlate it with protection,” says Ochando. “But I hope it will happen someday.” (Chow, NBC News6/14)

Sources

1/ https://Google.com/

2/ https://www.advisory.com/daily-briefing/2022/06/17/covid-immunity

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