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Infants whose mothers are vaccinated during pregnancy are better protected from severe COVID-19
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sauce:
Harasa, NB, etc. N Engl J Med.. 2022; doi: 10.1056 / NEJMoa2204399.
Disclosure: Harasa reports that she is receiving research support from the CDC and Sanofi Pasteur. See Surveys for disclosure of relevant financial information for all other authors.
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Infants under 6 months were better protected from the consequences of severe COVID-19 if the mother was vaccinated twice during pregnancy, according to the researchers.
Vaccination of pregnant mothers reduced the risk of COVID-19-related hospitalized babies by more than 50%. Natasha B. HarasaMD, MPH, Professor of Pediatrics at Vanderbilt University, and colleagues TNew England Journal of Medicine..
Previous studies have shown that vaccinated mothers give their babies anti-spiked immunoglobulin G antibodies and that infants retain the antibodies in 6 months. A study by Harasa and her colleagues goes one step further and shows the protective effect of the mother’s COVID-19 vaccination against hospitalization of the baby.
“The benefits of maternal vaccination for illnesses in 6-month-old babies have been previously demonstrated with other vaccine-preventable illnesses such as whooping cough and influenza,” they say.
In a case-control test-negative study, researchers compared the odds of full maternal vaccination during pregnancy for symptomatic infants <6 months old hospitalized with COVID-19 and infants hospitalized without COVID-19. Did. The researchers enrolled 1,049 infants between 1 July 2021 and 8 March 2022 — 537 cases of infants and 512 control infants.
Overall, the efficacy of vaccination during pregnancy for COVID-19-related hospitalizations in infants was 52% (95% CI, 33-65), but the number varied in response to the predominant mutation. For example, the efficacy during the delta period was 80% (95% CI, 60-90) and the efficacy during the Omicron wave was 38% (95% CI, 8-58).
The effect also depends on when the pregnant person was vaccinated. When women were vaccinated during the first 20 weeks of pregnancy, efficacy was 38% (95% CI, 3-60). After 20 weeks of gestation, efficacy increased to 69% (95% CI, 50-80).
In a related editorial, Sonia A. RasmussenMD, Professor of Pediatrics and Epidemiology, University of Florida, and Denise J. Jamison, MD, MPH, James Robert McCord, professor and chairman of the Department of Gynecology and Obstetrics at Emory University, said the study not only provided “convincing evidence that maternal vaccination is effective,” but also vaccination during pregnancy. He said he would raise questions about the optimal timing of the pregnancy.
“Given the increased risk of severe COVID-19 during pregnancy, we need to balance the benefits of maximizing infant protection with the risk of mothers delaying vaccination, so be at the right time. It’s difficult to decide, “they write. “Further research is needed to assess whether additional booster immunizations enhance infant protection in late pregnancy.”
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