Health
Pfizer says fine-tuned COVID-19 shots boost Omicron protection
Pfizer announced on Saturday that it is safe and functional to fine-tune the COVID-19 vaccine to better target Omicron variants.
The vaccination Currently used in the United States, it provides strong protection against severe COVID-19 illness and death, especially when people are boosted. However, these vaccines targeted the original coronavirus strain, and the emergence of epidemic Omicron variants significantly reduced their effectiveness against infection.
Due to the widespread prevalence of Omicron’s more contagious relatives, the Food and Drug Administration is considering ordering recipe changes for vaccines made by both Pfizer and rival Moderna. ..
Pfizer and its partner BioNTech have researched two different ways to update shots. A combination of boosters that target only Omicron or add Omicron protection to the original vaccine. They also tested whether to maintain today’s standard dose (30 micrograms) or double the intensity of the shot.
In a study of more than 1,200 middle-aged and older adults who had already been vaccinated three times, Pfizer said both booster approaches spurred a significant increase in antibodies to fight Omicron.
“Based on these data, we believe there are two very strong candidates for Omicron,” Pfizer CEO Albert Bourla said in a statement.
Pfizer’s Omicron-only booster elicited the strongest immune response against the mutant.
However, many experts say that combined shots may be the best approach. This is to add new protection against Omicron while preserving the proven benefits of the original COVID-19 vaccine. Pfizer said that one month after people received the combo shots, antibodies fighting Omicron increased 9-11 times. This is more than 1.5 times better than another dose of the original vaccine.
And importantly, preliminary laboratory studies have shown that fine-tuned shots also produce antibodies that can fight genetically distinct relatives of Omicrons named BA.4 and BA.5. However, those levels were barely high.
Moderna recently released similar results from a combination shot test that scientists call a “divalent” vaccine.
The study was not designed to track how well the updated booster prevented cases of COVID-19. Also, it is not clear how long the added protection will last.
However, the FDA’s scientific adviser will discuss the data publicly on Tuesday as it is working on whether to recommend changes to the vaccine recipe prior to similar decisions by other countries.
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The Associated Press’s Department of Health Sciences is supported by the Science Education Department of the Howard Hughes Medical Institute. AP is solely responsible for all content.
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