Health
Studies show that COVID-19 can cause metabolic problems by interfering with insulin signaling.
It is well understood that coronavirus disease 19 (COVID-19), despite being transmitted by the respiration of the SARS-CoV-2 virus, can have harmful effects far beyond the lungs. increase. Currently, Japanese researchers have identified critical genes that mediate the effects of SARS-CoV-2 infection on glycemic metabolism.
In a study published in June metabolismResearchers at Osaka University have shown that COVID-19 can cause metabolic problems and sometimes diabetes by interfering with insulin signaling.
COVID-19 is best known to cause respiratory illness, but it can also damage other organ systems. In particular, disruption of glycemic control can lead to new onset diabetes. However, it is unclear how infection with the SARS-CoV-2 virus will bring about these effects.
The insulin / IGF signaling pathway is an important pathway in the regulation of energy metabolism and cell survival. Therefore, we suspected that SARS-CoV-2 could affect this signaling pathway and cause problems with glycemic control. “
Lead author of the study, Jihoon Shin
To test this, researchers analyzed a dataset of gene expression from patients. In vivo When In vitro Infected with model SARS-CoV-2. They specifically searched for genes that were significantly overexpressed or underexpressed compared to uninfected patients, animals, or cells.
“The results were impressive,” said Ichiro Shimomura, senior author of the study. “SARS-CoV-2 infection affected the expression of insulin / IGF signaling pathway components in lung, liver, adipose tissue, and pancreatic cells. In addition, these changes were the activity of interferon regulator 1. It was partly due to the change (IRF1). “
By further investigation IRF1 Expression is elevated in elderly patients, men, obese individuals, and diabetic patients. The synergistic effect of SARS-CoV-2 on elderly, male gender, obesity, diabetes means increased expression of IRF1 and explains why these patients are more vulnerable to COVID-19. It may be.In addition, significant patients with COVID-19 were higher IRF1 Expression and reduction of insulin / IGF signaling pathway genes in the blood compared to non-critical patients.Finally, treat cells or animal models infected with SARS-CoV-2 with reduced hormonal factors. IRF1 Expression enhanced insulin / IGF signaling.
“Our findings suggest that increased SARS-CoV-2 infection impairs insulin / IGF signaling. IRF1 Expression, thereby disrupting glycemic metabolism.Decrease IRF1 Expression by treatment with factors such as dihydrotestosterone and dexamethasone may help mitigate the effects of COVID-19, “Shin said.
Given the devastating effects of COVID-19 on multiple organ systems, therapeutic strategies that can reduce the effects of the disease on glycemic metabolism can be very important.By experiencing these effects and identifying patients at high risk of intervening to reduce them IRF1 Activation, some of the serious consequences of COVID-19 can be avoided in sensitive populations.
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Journal reference:
Shin, J. , et al. (2022) SARS-CoV-2 infection impairs insulin / IGF signaling pathways in lung, liver, adipose tissue, and pancreatic cells via IRF1. metabolism. doi.org/10.1016/j.metabol.2022.155236..
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