Health
Cell therapy reverses syndromes like dementia in dogs
Biotechnology’s “all-new neurorepair approach” aims to reconstruct and replace brain cells lost in Alzheimer’s disease, which underlies clinical symptoms.
Behind the scenes, the company plans to launch the world’s first human clinical trial in 2024.
‘Light of hope’
A veterinary exam released this month, led by Skin2Neuron Stem cell research and treatmentAlzheimer’s disease has reversed a dementia-like syndrome that attacks many older pet dogs.
Dementia was reversed in more than half of dog patients, with a “clinically meaningful” improvement in 80%. The improvement usually lasted about two years.
Skin2Neuron supports a new approach as the “light of hope” for Alzheimer’s disease. It supports a completely different approach to the amyloid hypothesis of Alzheimer’s disease.
“Our goal is the ultimate cause of dementia. Loss of neurons and synapses. To do this, the patient’s own HFN cells were destroyed by the hippocampus, the center of memory of the brain, Alzheimer’s disease. Microinject directly into the area. “Describe the company.
Its primary therapeutic target is Alzheimer’s disease, but the technique also has the potential to treat neurodegenerative conditions such as Parkinson’s disease and amyotrophic lateral sclerosis.
Dog research
The company says the dog’s thinking neocortex and hippocampus resemble the human brain. Older dogs, on the other hand, often develop a dementia syndrome that resembles human dementia. Forgetfulness, frustration, lost children, wandering for no purpose, unrecognizable owners, experiencing sleep disorders, etc.
“I started this test 10 years ago because of the deep similarities between dog brain and human brain, and Alzheimer’s disease in dogs and Alzheimer’s disease in humans. I assumed it needed to work with a dog. The result exceeded my biggest expectations. “Co-founder Professor Michael Barrensela said.
“The hippocampus, the center of memory in the brain, is packed with baby neurons and new synapses, and is exactly where the cells arrived. It was more like day and night when compared to untreated dogs.” ..
Microscopic analysis confirmed that the dog suffered from classic Alzheimer’s disease. This means that cell therapy worked in the context of natural illness.
“Our dog patients also had many of the same health problems that older people face, which gives me even greater confidence.”Valensela said.
Studies: Valenzuela, M., Duncan, T., Abey, A. et al. Autologous skin-derived neural progenitor cell therapy reverses the Alzheimer-type dementia-like syndrome in dogs in proof-of-concept veterinary trials. Stem cell resolution13, 261 (2022). https://doi.org/10.1186/s13287-022-02933-w....
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