The Vaccine-Hesitant Moment | NEJM

1. World Health Organization. Influenza A (H1N1): pandemic 2009–2010. 2010 (https://www.who.int/emergencies/situations/influenza-a-(h1n1)-outbreak).

2. Black S, Rappuoli R. A crisis of public confidence in vaccines. Sci Transl Med 2010;2(61):61mr1–61mr1.

3. Schwarzinger M, Flicoteaux R, Cortarenoda S, Obadia Y, Moatti J-P. Low acceptability of A/H1N1 pandemic vaccination in French adult population: did public health policy fuel public dissonance? PLoS One 2010;5(4):e10199–e10199.

4. Ofri D. The emotional epidemiology of H1N1 influenza vaccination. N Engl J Med 2009;361:2594–2595.

5. Cascini F, Pantovic A, Al-Ajlouni Y, Failla G, Ricciardi W. Attitudes, acceptance and hesitancy among the general population worldwide to receive the COVID-19 vaccines and their contributing factors: a systematic review. EClinicalMedicine 2021;40:101113–101113.

6. Cooper S, Van Rooyen H, Wiysonge CS. COVID-19 vaccine hesitancy in South Africa: a complex social phenomenon. S Afr Med J 2021;111:702–703.

7. Dzinamarira T, Nachipo B, Phiri B, Musuka G. COVID-19 vaccine roll-out in South Africa and Zimbabwe: urgent need to address community preparedness, fears and hesitancy. Vaccines (Basel) 2021;9:250–250.

8. Ipsos. Covid-19 vaccine intent: Ipsos survey for the World Economic Forum. 2021 (https://www.ipsos.com/sites/default/files/ct/news/documents/2021-05/COVID-19-Vaccination%20Intent%20-April-2021-report.pdf).

9. Johnson NF, Velásquez N, Restrepo NJ, et al. The online competition between pro- and anti-vaccination views. Nature 2020;582:230–233.

10. UNICEF, World Health Organization. Progress towards global immunization goals — 2018. 2018 (https://www.who.int/docs/default-source/documents/immunization/data/progress-towards-global-immunization-goals-2018.pdf?sfvrsn=aa30c225_2).

11. Meeting of the Strategic Advisory Group of Experts on Immunization, November 2011 — conclusions and recommendations. Wkly Epidemiol Rec 2012;87:1–16.

12. MacDonald NE; SAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: definition, scope and determinants. Vaccine 2015;33:4161–4164.

13. World Health Organization. Ten threats to global health in 2019. 2019 (https://www.who.int/news-room/spotlight/ten-threats-to-global-health-in-2019).

14. Dubé E, Laberge C, Guay M, Bramadat P, Roy R, Bettinger J. Vaccine hesitancy: an overview. Hum Vaccin Immunother 2013;9:1763–1773.

15. Peretti-Watel P, Larson HJ, Ward JK, Schulz WS, Verger P. Vaccine hesitancy: clarifying a theoretical framework for an ambiguous notion. PLoS Curr 2015;7:6844c80ff9f5b273f34c91f71b7fc289–6844c80ff9f5b273f34c91f71b7fc289.

16. Goldenberg MJ. Vaccine hesitancy: public trust, expertise, and the war on science. Pittsburgh: University of Pittsburgh Press, 2021:3–3.

17. Larson HJ, Broniatowski DA. Volatility of vaccine confidence. Science 2021;371:1289–1289.

18. de Albuquerque Veloso Machado M, Roberts B, Wong BLH, van Kessel R, Mossialos E. The relationship between the COVID-19 pandemic and vaccine hesitancy: a scoping review of literature until August 2021. Front Public Health 2021;9:747787–747787.

19. Piot P, Larson HJ, O’Brien KL, et al. Immunization: vital progress, unfinished agenda. Nature 2019;575:119–129.

20. Davies P, Chapman S, Leask J. Antivaccination activists on the world wide web. Arch Dis Child 2002;87:22–25.

21. Jennings W, Stoker G, Bunting H, et al. Lack of trust, conspiracy beliefs, and social media use predict COVID-19 vaccine hesitancy. Vaccines (Basel) 2021;9:593–593.

22. Dolman AJ, Fraser T, Panagopoulos C, Aldrich DP, Kim D. Opposing views: associations of political polarization, political party affiliation, and social trust with COVID-19 vaccination intent and receipt. J Public Health (Oxf) 2022 January 25 (Epub ahead of print).

23. Kata A. Anti-vaccine activists, Web 2.0, and the postmodern paradigm — an overview of tactics and tropes used online by the anti-vaccination movement. Vaccine 2012;30:3778–3789.

24. DeStefano F, Thompson WW. MMR vaccine and autism: an update of the scientific evidence. Expert Rev Vaccines 2004;3:19–22.

25. The Lancet Child Adolescent Health. Vaccine hesitancy: a generation at risk. Lancet Child Adolesc Health 2019;3:281–281.

26. Akehurst C. France suspends hepatitis B immunisation for adolescents in schools. Euro Surveill 1998;2:1143–1143.

27. McLenon J, Rogers MAM. The fear of needles: a systematic review and meta-analysis. J Adv Nurs 2019;75:30–42.

28. Herman R, McNutt L-A, Mehta M, Salmon DA, Bednarczyk RA, Shaw J. Vaccination perspectives among adolescents and their desired role in the decision-making process. Hum Vaccin Immunother 2019;15:1752–1759.

29. Karafillakis E, Simas C, Jarrett C, et al. HPV vaccination in a context of public mistrust and uncertainty: a systematic literature review of determinants of HPV vaccine hesitancy in Europe. Hum Vaccin Immunother 2019;15:1615–1627.

30. Yang YT, Olick RS, Shaw J. Adolescent consent to vaccination in the age of vaccine-hesitant parents. JAMA Pediatr 2019;173:1123–1124.

31. Rosenbaum L. Escaping Catch-22 — overcoming Covid vaccine hesitancy. N Engl J Med 2021;384:1367–1371.

32. Plotkin SA, Offit PA, DeStefano F, et al. The science of vaccine safety: summary of meeting at Wellcome Trust. Vaccine 2020;38:1869–1880.

33. Lighter J. We’re ignoring the biggest cause of the measles crisis. New York Times. September 22, 2019 (https://www.nytimes.com/2019/09/22/opinion/anti-vaccine-parents.html).

34. Amin DP, Palter JS. COVID-19 vaccination hesitancy among healthcare personnel in the emergency department deserves continued attention. Am J Emerg Med 2021;48:372–373.

35. Suryadevara M, Handel A, Bonville CA, Cibula DA, Domachowske JB. Pediatric provider vaccine hesitancy: an under-recognized obstacle to immunizing children. Vaccine 2015;33:6629–6634.

36. Biswas N, Mustapha T, Khubchandani J, Price JH. The nature and extent of COVID-19 vaccination hesitancy in healthcare workers. J Community Health 2021;46:1244–1251.

37. Karafillakis E, Larson HJ. The paradox of vaccine hesitancy among healthcare professionals. Clin Microbiol Infect 2018;24:799–800.

38. Larson HJ, Jarrett C, Eckersberger E, Smith DMD, Paterson P. Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007–2012. Vaccine 2014;32:2150–2159.

39. Mesch GS, Schwirian KP. Social and political determinants of vaccine hesitancy: lessons learned from the H1N1 pandemic of 2009–2010. Am J Infect Control 2015;43:1161–1165.

40. Sallam M. COVID-19 vaccine hesitancy worldwide: a concise systematic review of vaccine acceptance rates. Vaccines (Basel) 2021;9:160–160.

41. Machingaidze S, Wiysonge CS. Understanding COVID-19 vaccine hesitancy. Nat Med 2021;27:1338–1339.

42. Carcelen AC, Prosperi C, Mutembo S, et al. COVID-19 vaccine hesitancy in Zambia: a glimpse at the possible challenges ahead for COVID-19 vaccination rollout in sub-Saharan Africa. Hum Vaccin Immunother 2022;18:1–6.

43. Aw J, Seng JJB, Seah SSY, Low LL. COVID-19 vaccine hesitancy — a scoping review of literature in high-income countries. Vaccines (Basel) 2021;9:900–900.

44. Sturgis P, Brunton-Smith I, Jackson J. Trust in science, social consensus and vaccine confidence. Nat Hum Behav 2021;5:1528–1534.

45. Baker JP. Mercury, vaccines, and autism: one controversy, three histories. Am J Public Health 2008;98:244–253.

46. Larson H. Poison pill: not all mercury is toxic. New Scientist. January 9, 2013 (https://www.newscientist.com/article/mg21728990-200-poison-pill-not-all-mercury-is-toxic/).

47. Centers for Disease Control and Prevention (CDC). Thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service. MMWR Morb Mortal Wkly Rep 1999;48:563–565.

48. Hurie MB, Saari TN, Davis JP. Impact of the joint statement by the American Academy of Pediatrics/US Public Health Service on thimerosal in vaccines on hospital infant hepatitis B vaccination practices. Pediatrics 2001;107:755–758.

49. Institute of Medicine. Immunization safety review: vaccines and autism. Washington, DC: National Academies Press, 2004.

50. Motta M, Stecula D. Quantifying the effect of Wakefield et al. (1998) on skepticism about MMR vaccine safety in the U.S. PLoS One 2021;16(8):e0256395–e0256395.

51. Jenness SM, Aavitsland P, White RA, Winje BA. Measles vaccine coverage among children born to Somali immigrants in Norway. BMC Public Health 2021;21:668–668.

52. Larson HJ. Stuck: how vaccine rumors start — and why they don’t go away. New York: Oxford University Press, 2020.

53. Donzelli G, Palomba G, Federigi I, et al. Misinformation on vaccination: a quantitative analysis of YouTube videos. Hum Vaccin Immunother 2018;14:1654–1659.

54. Covolo L, Ceretti E, Passeri C, Boletti M, Gelatti U. What arguments on vaccinations run through YouTube videos in Italy? A content analysis. Hum Vaccin Immunother 2017;13:1693–1699.

55. Briones R, Nan X, Madden K, Waks L. When vaccines go viral: an analysis of HPV vaccine coverage on YouTube. Health Commun 2012;27:478–485.

56. Ache KA, Wallace LS. Human papillomavirus vaccination coverage on YouTube. Am J Prev Med 2008;35:389–392.

57. Keelan J, Pavri-Garcia V, Tomlinson G, Wilson K. YouTube as a source of information on immunization: a content analysis. JAMA 2007;298:2482–2484.

58. Tomacruz S. A year after Dengvaxia: immunization drops, measles outbreaks soar. Rappler. December 1, 2018 (https://www.rappler.com/newsbreak/in-depth/217912-dengvaxia-one-year-after-outbreaks-series-part-1/).

59. Gørtz M, Brewer NT, Hansen PR, Ejrnæs M. The contagious nature of a vaccine scare: how the introduction of HPV vaccination lifted and eroded MMR vaccination in Denmark. Vaccine 2020;38:4432–4439.

60. Immunization stress-related responses. Geneva: World Health Organization, 2019 (https://apps.who.int/iris/bitstream/handle/10665/330277/9789241515948-eng.pdf).

61. Simas C, Munoz N, Arregoces L, Larson HJ. HPV vaccine confidence and cases of mass psychogenic illness following immunization in Carmen de Bolivar, Colombia. Hum Vaccin Immunother 2019;15:163–166.

62. Haruyama R, Obara H, Fujita N. Japan resumes active recommendations of HPV vaccine after 8.5 years of suspension. Lancet Oncol 2022;23:197–198.

63. Larson HJ, Wilson R, Hanley S, Parys A, Paterson P. Tracking the global spread of vaccine sentiments: the global response to Japan’s suspension of its HPV vaccine recommendation. Hum Vaccin Immunother 2014;10:2543–2550.

64. Simms KT, Hanley SJB, Smith MA, Keane A, Canfell K. Impact of HPV vaccine hesitancy on cervical cancer in Japan: a modelling study. Lancet Public Health 2020;5(4):e223–e234.

65. Puri N, Coomes EA, Haghbayan H, Gunaratne K. Social media and vaccine hesitancy: new updates for the era of COVID-19 and globalized infectious diseases. Hum Vaccin Immunother 2020;16:2586–2593.

66. Liu R, Li GM. Hesitancy in the time of coronavirus: temporal, spatial, and sociodemographic variations in COVID-19 vaccine hesitancy. SSM Popul Health 2021;15:100896–100896.

67. Wilson SL, Wiysonge C. Social media and vaccine hesitancy. BMJ Glob Health 2020;5(10):e004206–e004206.

68. García-Saisó S, Marti M, Brooks I, et al. The COVID-19 infodemic. Rev Panam Salud Publica 2021;45:e56–e56.

69. Fridman A, Gershon R, Gneezy A. COVID-19 and vaccine hesitancy: a longitudinal study. PLoS One 2021;16(4):e0250123–e0250123.

70. Muric G, Wu Y, Ferrara E. COVID-19 vaccine hesitancy on social media: building a public Twitter data set of antivaccine content, vaccine misinformation, and conspiracies. JMIR Public Health Surveill 2021;7(11):e30642–e30642.

71. Piedrahita-Valdés H, Piedrahita-Castillo D, Bermejo-Higuera J, et al. Vaccine hesitancy on social media: sentiment analysis from June 2011 to April 2019. Vaccines (Basel) 2021;9:28–28.

72. Bragazzi NL, Gianfredi V, Villarini M, et al. Vaccines meet big data: state-of-the-art and future prospects. From the classical 3Is (“isolate-inactivate-inject”) vaccinology 1.0 to vaccinology 3.0, vaccinomics, and beyond: a historical overview. Front Public Health 2018;6:62–62.

73. The Delphi Group. COVID-19 Symptom Survey: topline report on COVID-19 vaccination in the United States, survey waves 6–8, January 10–February 27, 2021. March 12, 2021 (https://www.cmu.edu/delphi-web/surveys/CMU_Topline_Vaccine_Report_20210312.pdf).

74. Salomon JA, Reinhart A, Bilinski A, et al. The US COVID-19 Trends and Impact Survey: continuous real-time measurement of COVID-19 symptoms, risks, protective behaviors, testing, and vaccination. Proc Natl Acad Sci U S A 2021;118(51):e2111454118–e2111454118.

75. Collis A, Garimella K, Moehring A, et al. Global survey on COVID-19 beliefs, behaviors, and norms. Cambridge, MA: MIT Sloan School of Management, November 30, 2020 (https://covidsurvey.mit.edu/covid_survey_files/COVID_BBN_survey_report.pdf).

76. Reinhart A, Kim E, Garcia A, LaRocca S. Using the COVID-19 Symptom Survey to track vaccination uptake and sentiment in the United States. Pittsburgh: CMU Delphi Group, January 28, 2021 (https://delphi.cmu.edu/blog/2021/01/28/using-the-covid-19-symptom-survey-to-track-vaccination-uptake-and-sentiment-in-the-united-states/).

77. Ratzan S, Schneider EC, Hatch H, Cacchione J. Missing the point — how primary care can overcome Covid-19 vaccine “hesitancy.” N Engl J Med 2021;384(25):e100.

78. Gallup. Wellcome global monitor. 2018 (https://wellcome.org/sites/default/files/wellcome-global-monitor-2018.pdf).

79. CUNY School of Public Health. Vaccine confidence grows under new administration, latest CUNY SPH survey reveals. January 2021 (https://sph.cuny.edu/research/covid-19-tracking-survey/january-vaccines/).

80. Hamel L, Lopes L, Kearney A, Brodie M. KFF COVID-19 Vaccine Monitor: March 2021. March 30, 2021 (https://www.kff.org/coronavirus-covid-19/poll-finding/kff-covid-19-vaccine-monitor-march-2021/).