Health
Studies reveal the structure of human endogenous reverse transcriptase-ScienceDaily
According to a study co-authored by Rutgers researchers, the crystalline structure of human endogenous reverse transcriptase is a well-known and manageable drug target that helps design drugs to treat cancer and other diseases. Similar to reverse transcriptase.
Research published in Minutes of the National Academy of Sciences (PNAS), Describes the first-ever high-resolution three-dimensional structure of endogenous reverse transcriptase, especially human endogenous retrovirus K (HERV-K) reverse transcriptase (RT). Past studies have shown that a significant portion of the human genome is composed of repetitive elements that are relics of past viral infections associated with a variety of serious diseases, including cancer.
Studies show that this structure provides therapeutic opportunities for RT inhibitors (HIV infection or AIDS, as well as antiretroviral drugs used to treat hepatitis B) in cancer, autoimmune and neurodegenerative diseases. increase.
“This study represents an important step forward in our understanding of endogenous retroviruses and how they are targeted to treat disease,” said the Ratgars Center for Advanced Biotechnology Medicine. ROME Therapeutics, a resident faculty member of (CABM) and a biotechnology company.
“Characterizing the structure of HIVRT was an important turning point in designing new drugs to combat the deadly virus,” said Rutgers, a prominent professor and board professor of chemistry and chemical biology. Arnold says. “Similarly, deeper insights into human endogenous RT may pave the way for new classes of treatment for cancer and other serious illnesses.”
Previous studies have shown that repetitive elements in the genome, such as HERV-K, are frequently overexpressed in cancer and induce biological viral mimicry reactions that can alter the tumor microenvironment.
The study is a biotechnology company that aims to develop new therapies for cancer and autoimmune diseases by studying the dark genome, which is a vast range of unknown genetic material that makes up more than 60% of the human genome. Co-authored by a ROME Therapeutics researcher. -For drug development.
“In this publication, we first describe the crystal structure of an endogenous reverse transcriptase known as HERV-K RT and show that it has significant similarities to the well-known HIV reverse transcriptase as an easy-to-use drug target. I am. ” ROME Chief Scientific Officer Dennis Zara. “This achievement is a milestone in the field of the dark genome, highlighting the opportunity for structure-based drug design based on established antiviral targets present in the human genome. This work is ROME’s preeminent task. The result of a great collaboration between structural biology teams, and the world’s leading crystallists. “
Story source:
material Provided by Rutgers University.. Note: Content can be edited in style and length.
|
Sources 2/ https://www.sciencedaily.com/releases/2022/06/220630164700.htm The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
