Health
Researchers assess brain circuits involved in social defeat stress-induced sleep in mice
According to new research, the stress surrounding being defeated by another mouse activates the mouse’s midbrain cells, promotes sleep, and reduces anxiety. This result highlights neural circuits in the brain and “leads to future interventions in rodents and possibly humans after stressful experiences such as cognitive therapy, drug therapy, or one day genetic interference. May help, “says Marian Joels. E. Ronald de Kloet from a related perspective.
Stress can cause insomnia, and vice versa. Chronic stress is known to increase rapid eye movement (REM) sleep. These observations hypothesized that sleep is an important adaptive response to stressful situations and helps to improve its negative physiological and psychological effects. In mice, social defeat stress (SDS), a stress response caused by the loss of social conflict, is often used as a model for psychosocial stress. Researchers have discovered that SDS can subsequently put some defeated animals to sleep. However, the underlying mechanisms of how these events trigger enhanced sleep remain elusive. Here, Xiao Yu allows his colleagues to evaluate the brain circuits involved in SDS-induced sleep in mice.
excellent et al. In the ventral tegmental area (VTA) of the midbrain, we found a small group of neurons dedicated to detecting post-SDS stress and inducing restorative sleep. Studies show that a subset of gamma-aminobutyric acid (GABA) -somatostatin neurons receive stress inputs and, when activated, suppress the release of corticotropic pin-releasing factor (CRF) while enhancing REM and non-rem sleep for several hours. Promote). Together, sleep initiated through this process reduced stress levels, reduced stress-induced anxiety in mice, and restored mental and physical function. Anxiety and corticotropin levels remained elevated after stress in SDS-induced sleep-deprived mice.
In a related perspective, Joëls and de Kloet state that “not all individuals respond to social defeat with sleep attacks.” They state that this individual difference “needs to be further investigated in a larger group of mice, which will also help to investigate the robustness of current exploratory studies.”
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Journal reference:
Yu, X. , et al. (2022) Certain circuits in the midbrain detect stress and induce restorative sleep. Chemistry. doi.org/10.1126/science.abn0853..
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