Health
SARS-CoV-2 causes genetic and functional changes in platelets
COVID-19 can cause changes in platelet levels and can cause serious health damage to heart attacks, strokes and other infected individuals.
The University of Utah experts Investigation The fact that inflammatory proteins produced by the body during infection can significantly alter platelets, making them hyperactive and prone to lethal thrombosis.
This finding is important because a better understanding of the underlying causes can lead to finding potential treatment options that can prevent them from occurring in infected individuals.
“Our findings add an important element to a jigsaw puzzle called COVID-19. News Medical says that inflammation and systemic changes caused by infections affect platelet function and cause platelets to aggregate faster. We can see why the number of blood clots is increasing in COVID patients Ph.D., senior author of the study and assistant professor of internal medicine.
Coronavirus infection is already known to be associated with an increased risk of blood coagulation, which can lead to heart problems and organ failure in some people, especially those with obesity, diabetes, and high blood pressure levels. I will.
Therefore, researchers looking to see what was happening studied 41 hospitalized COVID-19 patients. Seventeen of them were treated in the intensive care unit, nine of which received mechanical ventilator support. They compared blood samples from these patients with blood samples from healthy people of the same age group.
Researchers have discovered that the new coronavirus appears to cause genetic changes in platelets. They also studied a key component of thrombus formation in a laboratory study and showed that platelets from COVID-19 patients aggregate more easily.
Findings suggest that these changes may have significantly altered the way platelets interact with the immune system, which in turn could cause severe lung injury.
Platelets are small blood cells that cause blood clots to form to prevent bleeding. In the case of COVID-19, researchers found that the inflammation caused by a coronavirus infection affects the cells that produce platelets, overactivating them and causing genetic changes that can cause fatal blood clotting. I believe it can cause.
They also showed that pretreatment of platelets from COVID-19 patients with aspirin can prevent hyperactivity.
The findings show that aspirin may help improve outcomes, but researchers warn against using drugs to treat COVID-19 unless recommended by health care providers ..
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