Using a “mini-brain” developed in the lab, scientists have shown that SARS-CoV-2 can directly infect brain cells

Baltimore — Believe it or not, scientists are not yet aware of all the symptoms that COVID-19 can cause. Early reports from Wuhan, China, show that more than one-third of coronavirus patients (36%) Showing neurological symptoms.. It remains unclear whether the virus infects brain cells or whether these symptoms are by-products of other things happening in the body. Scientists at Johns Hopkins have shown that a “miniature brain” produced in the laboratory can be used to directly infect brain cells with the SARS-CoV-2 virus.

These futuristic mini-brains are a type of organoid, a tissue culture grown from human cells that mimic organs. Because some cells express the receptor ACE2, researchers believe that coronavirus can infect brain cells. Previous studies have shown that ACE2 is a receptor protein that creates the entrance to the SARS-CoV-2 virus In the lungs.. Researchers speculated that the coronavirus might also use this pathway in the brain.

Can SARS-CoV-2 cross the blood-brain barrier?

It is usually very difficult to get infected because the brain has a special line of defense called “”Blood-brain barrier.This protective layer helps protect the brain from many viruses and bacteria.

“It has not yet been shown whether the SARS-CoV-2 virus crosses this barrier,” explained Thomas Hartung, MD, MD, Chair of Evidence-Based Toxicology at Bloomberg School of Public Health in Hopkins. so Press release.. “But it is known that the barrier is disrupted by the severe inflammation that is observed in COVID-19 patients.”

When researchers introduced SARS-CoV-2 into the mini-brain, the virus was able to cross the blood-brain barrier and infect the brain directly.

Warning to pregnant women

The authors note one great implication from the results of their experiments for women. In the early stages of development, the brain lacks a functional blood-brain barrier and some cells already have the ACE2 receptor. Requires special attention Pregnant To prevent embryo infection.

“This study is another important step in understanding how infectious diseases cause symptoms and where to address them. COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing Dr. William Bishay, a medical professor at Johns Hopkins University School of Medicine and leader of the infectious disease team for research, concludes.

of Investigation Published in Altex: alternative to animal testing..

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