Connect with us


What is the optimal LDL cholesterol level for patients with cardiovascular disease?

What is the optimal LDL cholesterol level for patients with cardiovascular disease?


High blood pressure in low-density lipoprotein cholesterol (LDL-C) is a major causative factor in coronary heart disease. Lowering LDL levels with medicine and / or diet is known to reduce the risk of cardiovascular disease.The effectiveness of low LDL levels in reducing the risk of vascular events in atherosclerosis is discussed in a recently published article in the journal. North American Endocrinology and Metabolism Clinic..

Study: LDL Cholesterol — How Low Can It Be? Image Credit: Corona Borealis Studio / Shutterstock
study: LDL Cholesterol — How Low Can It Be? Image Credit: Corona Borealis Studio / Shutterstock


Hypercholesterolemia is a condition characterized by very high levels of LDL in the blood. Because LDL accumulates in the arterial wall, it is considered “bad” cholesterol and causes arterial narrowing and hardening, as well as obstruction of blood flow. Initially, blood cholesterol levels of 300 mg / dL were considered the upper limit of normal based on demographics.

Almost all mammalian nucleated cells can synthesize cholesterol, and LDL is only needed to recycle it. Newborn humans have very low levels of LDL compared to infants and adults. The large amount of cholesterol required for fetal brain development is synthesized in the brain.

Diseases caused by LDL receptor mutations, such as familial hypercholesterolemia, can significantly increase blood LDL levels, leading to the development of myocardial infarction and other atherosclerosis.

The effectiveness of lowering blood LDL levels in reducing the risk of coronary heart disease was first discussed at the 1984 National Institutes of Health (NIH) consensus conference. In 1987, the first statin drug, lovastatin, was introduced to the market.Showed important Effectiveness For controlling blood LDL levels. Since then, many highly effective cholesterol-lowering drugs have been developed, including atorvastatin, rosuvastatin, and ezetimibe.

Most cholesterol-lowering drugs have been shown to be highly effective in lowering blood LDL levels, which reduces the risk of myocardial infarction, stroke, and other atherosclerosis. Treatment with monoclonal antibodies targeting PCSK9 (liver protease) (alirocumab and evolocumab) in combination with statins has been shown to reduce LDL levels by 50%.

According to current European guidelines, a blood LDL level of 40 mg / dL is considered the target threshold for treating patients with two or more major atherosclerosis.

Cholesterol-lowering drug safety profile

The backbone of cholesterol-lowering therapy, statins are associated with several harmful side effects, including muscle damage and newly developed diabetes. However, there is ample evidence that muscle symptoms associated with statin treatment develop due to the nosebo effect, a negative treatment outcome resulting from patient distrust of treatment.

Treatment with alirocumab for more than 6 months has been shown to reduce LDL levels to less than 15 mg / dL without causing serious adversity such as cognitive impairment, newly developed diabetes, and hemorrhagic stroke. .. Similar results have been observed with evolocumab treatment.

An 80% to 90% reduction in PCSK9 blood levels via Inclisiran (siRNA) has been shown to reduce LDL levels by 50% without causing serious side effects. Taken together, these observations show that the ultra-low levels of LDL achieved by cholesterol-lowering therapy are not associated with major health hazards.

Usefulness of ultra-low LDL levels

Many clinical trials have been conducted to investigate the effects of lower LDL levels on reducing cardiovascular risk. According to these studies, the risk of cardiovascular events can be reduced by 22% per 1 mmol / L reduction in LDL levels. Blood LDL levels of 25-50 mg / dL are considered optimal for patients with atherosclerosis. However, it has been observed that lowering LDL levels below 25 mg / dL has no additional therapeutic effect on these patients.

Based on the available evidence collected from large cardiovascular outcome clinical trials, LDL levels below 40 mg / dL are believed to be beneficial in significantly reducing the risk of cardiovascular events. increase.

Highlighted observations

Based on the results of large clinical trials, the current article highlights two key points. Blood LDL levels below 40 mg / dL are set as the target threshold for cholesterol-lowering drugs in patients with two or more atherosclerosis.

No adverse side effects have been reported for LDL levels of 25 mg / dL, but further lowering of LDL levels may not bring additional benefits to patients with cardiovascular disease.




The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: cgurgu@internetmarketingcompany.BizWebsite: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos


to request, modification Contact us at Here or